Association between variations in the TLR4 gene and incident type 2 diabetes is modified by the ratio of total cholesterol to HDL-cholesterol

Melanie Kolz¹ , Jens Baumert¹ , Martina Müller¹^,2 , Natalie Khuseyinova³ , Norman Klopp¹ , Barbara Thorand¹ , Christine Meisinger¹^,4 , Christian Herder⁵ , Wolfgang Koenig³ and Thomas Illig¹

¹Institute of Epidemiology, Helmholtz Center Munich, German Research Center for Environmental Health, Neuherberg, Germany

²Institute of Medical Information Processing, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany

³Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany

⁴Central Hospital of Augsburg, Germany

⁵Institute for Clinical Diabetes Research, German Diabetes Center, Leibniz Center at Heinrich Heine University, Düsseldorf, Germany

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BMC Medical Genetics 2008, 9:9doi:10.1186/1471-2350-9-9


Published:	25 February 2008

Additional files

Additional file 1:

Results of interaction effect models including three-way interaction terms between sex, TC/HDL-C and the genetic variants. Results of haplotype and SNP association analysis for men and women combined including three-way interaction terms between sex, TC/HDL-C and the genetic variants.

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