Table 4

Association of TCF7L2 variant rs7903146 on dichotomization of the patient cohort based on N34S SPINK1 and L26V CTSB mutation status

N34S SPINK1

L26V CTSB

Wild

Mutant

Wild

Mutant

rs7903146

MAF

MAF

OR (95% CI)

P

MAF

MAF

OR (95% CI)

P

Total Cohort

(n = 307)

(n = 148)

(n = 165)

(n = 236)

0.29

0.28

0.95 (0.70–1.30)

0.75

0.28

0.28

1.01 (0.74–1.38)

0.95

FCPD

(n = 129)

(n = 49)

(n = 65)

(n = 78)

0.31

0.35

1.13 (0.69–1.85)

0.63

0.28

0.36

1.42 (0.86–2.36)

0.17

TCP

(n = 178)

(n = 99)

(n = 100)

(n = 158)

0.27

0.24

0.87 (0.58–1.29)

0.48

0.28

0.24

0.83 (0.55–1.24)

0.36

FCPD vs TCP

OR

1.22 (0.85–1.73)

1.59 (0.93–2.70)

0.98 (0.60–1.61)

1.69 (1.11–2.56)

P

0.27

0.09

0.95

0.013*

TCP, tropical calcific pancreatitis; FCPD, fibro-calculous pancreatic diabetes; MAF, Minor allele frequency; OR, odds ratio; CI, confidence interval; P, p value;

Mahurkar et al. BMC Medical Genetics 2008 9:80   doi:10.1186/1471-2350-9-80