Table 2 |
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|
Association of TCF7L2 variants with type 2 diabetes mellitus among UK-resident South Asians |
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|
SNP |
Allele |
Diabetic subjects Fa |
Control subjects Fa |
Genotype |
Diabetic subjects n (%)b |
Control subjects n (%)b |
Allelic ORc (95% CI) |
Het ORc,d (95% CI) |
Hom ORc,d (95% CI) |
|
|
|||||||||
|
T |
0.65 |
0.71 |
TT |
362 (43.7) |
226 (51.7) |
1.29 (1.09 – 1.54) |
1.31 (1.02 – 1.68) |
1.65 (1.12 – 2.44) |
|
|
rs7901695 |
CT |
355 (42.9) |
169 (38.7) |
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|
C |
0.35 |
0.29 |
CC |
111 (13.4) |
42 (9.6) |
p = 3.60 × 10-3 |
p = 0.032 |
p = 0.012 |
|
|
|
|||||||||
|
C |
0.64 |
0.71 |
CC |
352 (42.5) |
222 (51.4) |
1.31 (1.11 – 1.56) |
1.37 (1.07 – 1.76) |
1.66 (1.13 – 2.44) |
|
|
rs7903146 |
CT |
360 (43.5) |
166 (38.4) |
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|
T |
0.36 |
0.29 |
TT |
116 (14.0) |
44 (10.2) |
p = 1.96 × 10-3 |
p = 0.014 |
p = 9.74 × 10-3 |
|
|
|
|||||||||
|
G |
0.53 |
0.59 |
GG |
229 (27.5) |
159 (36.5) |
1.30 (1.11 – 1.54) |
1.46 (1.12 – 1.89) |
1.65 (1.18 – 2.30) |
|
|
rs11196205 |
CG |
417 (50.2) |
199 (45.6) |
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|
C |
0.47 |
0.41 |
CC |
185 (22.3) |
78 (17.9) |
p = 1.10 × 10-3 |
p = 5.29 × 10-3 |
p = 3.33 × 10-3 |
|
|
|
|||||||||
|
G |
0.68 |
0.73 |
GG |
382 (46.8) |
241 (55.4) |
1.26 (1.05 – 1.51) |
1.43 (1.11 – 1.83) |
1.37 (0.92 – 2.05) |
|
|
rs12255372 |
GT |
346 (42.3) |
153 (35.2) |
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|
T |
0.32 |
0.27 |
TT |
89 (10.9) |
41 (9.4) |
p = 3.60 × 10-3 |
p = 5.23 × 10-3 |
p = 0.127 |
|
|
|
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|
aF = Allele frequency. bGenotype frequency expressed as number of individuals, n – values in parentheses indicate percentage. cOR = odds ratio, 95% CI = 95% confidence interval. dGenotype odds ratios calculated compared with homozygotes for common allele; het OR = odds ratio for heterozygous genotype, hom OR = odds ratio for minor allele homozygous genotype. All values were calculated using the full dataset, the minimum age of control subjects being 35 years. |
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|
Rees et al. BMC Medical Genetics 2008 9:8 doi:10.1186/1471-2350-9-8 |
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