Table 2 |
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|
Genotype frequencies and minor allele frequencies of genetic polymorphisms in ulcerative colitis patients and controls. |
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|
Controls Frequencies (%) |
UC patients Frequencies (%) |
P-value |
OR (95% CI)* |
|
|
|
||||
|
MTHFR 677 |
||||
|
CC# |
40.9 |
38.1 |
||
|
CT# |
43.3 |
45.2 |
0.6053a |
1.12 (0.72–1.75) |
|
TT |
15.8 |
16.7 |
0.6821a |
1.13 (0.62–2.05) |
|
Total number of patients analysed |
215 |
168 |
||
|
Allele T |
0.37 |
0.39 |
0.6027 |
1.09 (0.81–1.46) |
|
MTHFR 1298 |
||||
|
AA# |
66.2 |
69.4 |
||
|
AC |
29.1 |
28.1 |
0.7277a |
0.92 (0.58–1.46) |
|
CC |
4.7 |
2.5 |
0.2631a |
0.51 (0.15–1.66) |
|
Total number of patients analysed |
213 |
160 |
||
|
Allele C |
0.19 |
0.17 |
0.3455 |
0.86 (0.59–1.26) |
|
MTR 2756 |
||||
|
AA# |
83.5 |
73.7 |
||
|
AG |
15.1 |
23.1 |
0.0422a |
1.72 (1.02–2.92) |
|
GG |
1.4 |
3.2 |
0.1899a |
2.64 (0.62–11.25) |
|
Total number of patients analysed |
218 |
156 |
||
|
Allele G |
0.09 |
0.15 |
0.0137 |
1.81 (1.15–2.84) |
|
MTRR 66 |
||||
|
AA# |
58.0 |
53.7 |
||
|
AG |
35.6 |
38.4 |
0.4839a |
1.17 (0.76–1.79) |
|
GG |
6.4 |
7.9 |
0.4746a |
1.34 (0.60–2.99) |
|
Total number of patients analysed |
219 |
164 |
||
|
Allele G |
0.24 |
0.27 |
0.2401 |
1.18 (0.85–1.64) |
|
TCN2 776 |
||||
|
CC# |
21.8 |
18.5 |
||
|
CG |
38.9 |
45.2 |
0.3358a |
1.26 (0.79–2.01) |
|
GG |
39.3 |
36.3 |
0.7835a |
1.09 (0.61–1.95) |
|
Total number of patients analysed |
216 |
146 |
||
|
Allele G |
0.58 |
0.59 |
0.9447 |
1.0 (0.74–1.35) |
|
|
||||
|
*(OR: unadjusted odds ratio; 95 CI%: 95% confidence interval) Abbreviations :methylenetetrahydrofolate reductase (MTHFR), methionine synthase (MTR), methylenetetrahydrofolate reductase (MTRR) and transcobalamin (TCN2) # Dominant genotype. a Comparison with dominant genotype. |
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|
Chen et al. BMC Medical Genetics 2008 9:78 doi:10.1186/1471-2350-9-78 |
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