Figure 2.

Phylogeny of the MSH2 Met688Val and Ala848Ser variants. Multiple sequence alignment of the hMSH2 polypeptide sequence and orthologues from other species were generated using the ClustalW algorithm [31]. The following polypeptide sequences were used in the alignment: P43246 (Human; Homo sapiens), CAA57049 (Mouse; Mus musculus), S53609 (Frog; Xenopus laevis), XP 426110 (Chicken; Gallus gallus) and CAB42554 (Maize; Zea mays).