Table 1

Single SNP Analysis

SNP
Gene*
Location*
2 × 2 McNemar's test p-value
3 × 3 McNemar's test p-value
Likelihood Ratio Test p-value
Odds Ratio (95% C.I.) of most likely mode of inheritance
Likelihood Ratio Test Model

rs800292
CFH
1q32
0.0005
1.6766E-05
0.0020
0.295(0.126–0.693)
Additive
rs572515
CFH
1q32
1.1422E-06
2.1771E-09
7.0012E-07
4.619(2.288–9.326)
Additive
rs7529589
CFH
1q32
0.0003
1.6852E-05
1.2034E-05
8.403(2.670–26.442)
Recessive
rs1061170
CFH
1q32
0.0002
3.9821E-05
1.9045E-05
7.382(2.495–21.838)
Recessive
rs12038333
CFH
1q32
0.0001
1.7989E-06
8.3182E-06
3.151(1.707–5.819)
Recessive
rs203674
CFH
1q32
5.7447E-06
5.0608E-08
4.3995E-06
3.914(2.020–7.585)
Additive
rs10801575
~CFH
~1q32
0.0304
0.0315
0.0108
0.370(0.174–0.785)
Dominant
rs1853883
CFHR4
1q32
0.0001
6.9750E-06
0.0003
2.687(1.519–4.751)
Additive
rs3790414
CFHR2
1q31-q32.1
0.0018
0.0002
0.0137
0.424(0.206–0.876)
Additive
rs1759016
CFHR5
1q22-q23
0.0092
0.0037
0.0092
0.465(0.262–0.827)
Additive
rs10922152
CFHR5
1q22-q23
0.0007
0.0001
0.0014
0.434(0.258–0.730)
Additive
rs10922153
CFHR5
1q22-q23
0.0002
1.0290E-05
0.0004
0.389(0.224–0.677)
Additive
rs6663083
?
1q31-1q32
0.0003
1.6704E-05
0.0008
0.419(0.248–0.707)
Additive
rs2990510
F13B
1q31-q32.1
0.0438
0.0395
0.1003
2.462(0.801–7.571)
Recessive
rs6003
F13B
1q31-q32.1
0.0153
0.0022
0.0025
0.162(0.041–0.631)
Additive
rs1412632
?
1q31-1q32
0.0153
0.0022
0.0030
0.165(0.042–0.645)
Additive
rs1412631
?
1q31-1q32
0.0098
0.0005
0.0013
0.110(0.022–0.557)
Additive
rs12677
ASPM
1q31
0.0098
0.0005
0.0019
0.127(0.026–0.609)
Additive
rs4915337
ASPM
1q31
0.0614
0.0233
0.0067
0.182(0.045–0.740)
Additive
rs1888991
ASPM
1q31
0.0244
0.0051
0.0044
0.175(0.044–0.696)
Additive
rs6677082
ASPM
1q31
0.0244
0.0051
0.0048
0.175(0.044–0.695)
Additive
rs6656448
ZBTB41
1q31.3
0.0218
0.0054
0.0042
0.209(0.063–0.694)
Additive
rs9288410
MAP2
2q34-q35
0.5563
0.3721
0.0294
1.923(0.885–4.179)
Recessive
rs304039
ITPR1
3p26-p25
0.6774
0.7070
0.1035
1.943(0.858–4.396)
Recessive
rs304041
ITPR1
3p26-p25
0.5896
0.4206
0.1035
1.943(0.858–4.396)
Recessive
rs1038639
ITPR1
3p26-p25
1.0000
0.9062
0.4345
0.731(0.332–1.610)
Dominant
rs1447338
?
4q34-4q35
0.5419
0.4856
0.2949
1.350(0.730–2.497)
Additive
rs7090030
ADD3
10q24.2-q24.3
1.0000
1.0000
0.5834
0.485(0.035–6.710)
Additive
rs11194995
ADD3
10q24.2-q24.3
1.0000
1.0000
0.5834
0.485(0.035–6.710)
Additive
rs11194996
ADD3
10q24.2-q24.3
1.0000
1.0000
0.9217
0.881(0.071–10.862)
Additive
rs11195001
ADD3
10q24.2-q24.3
1.0000
1.0000
1.0000
0.485(0.035–6.715)
Additive
rs2014307
PLEKHA1/HTRA1
10q26
6.6872E-06
8.1056E-07
3.7092E-05
0.240(0.111–0.520)
Additive
rs949252
GPR152
11q13.1
0.4795
0.4795
0.1979
2.006(0.115–35.135)
Dominant
rs7124630
TMEM134
11q13.1
0.4795
0.0000
0.3864
1.004E-07(0.000-Inf)
Additive
rs11575221
STAT2
12q13-12q14
1.0000
1.0000
0.4358
2.740(0.204–36.835)
Additive

Abbreviations: SNP, single nucleotide polymorphism; C.I., confidence interval.

* Gene and location of each SNP determined using ENSEMBL [15].

Zhang et al. BMC Medical Genetics 2008 9:51   doi:10.1186/1471-2350-9-51