Table 3

Distribution of significant associations between non-APOE polymorphisms and AD. LD = linkage disequilibrium, MDR = multi-dimensionality reduction, LR = logistic regression, AoO = age of onset, ●● = significant at the modified FDR α level, or, in the case of MDR, according to a priori significance criteria: for significant MDR results, the proportion of 10 CVs that identified this model as best and proportion of 10 CVs in which this model produced a training accuracy >0.5 are listed; ● = approaching significance (p <= 0.05, the experimentwise α). Note the consistent identification of lhcgr2/APOE as a significant interaction in males. CV = cross-validation.

Loci

Dataset

χ2

AoO

LD

MDR

LR


lhb2

lhcgr2

●●

(p = 0.001; α = 0.0077)

lhcgr1/lhb1

lhcgr1/lhb5

lhcgr2/APOE

●●

(p = 0.002; α = 0.0077)

●●

(0.8 CVs; 0.7 CVs)

●●

(p = 0.003; α = 0.0077)

lhcgr5/lhb2

lhcgr5/lhb4

lhcgr5/lhb5

lhcgr2/lhcgr5/APOE

●●

(0.7 CVs; 0.9 CVs)

lhcgr2/APOE

lhb3/APOE

●●

(p < 0.0001; α = 0.0081)

lhb5/APOE

●●

(0.5 CVs; 1.0 CVs)

lhcgr1/lhb1

Total

lhb3/APOE

Total

●●

(p < 0.0001; α = 0.0082)

lhcgr1/lhcgr2/APOE

Total

●●

(0.6 CVs; 0.9 CVs)


Haasl et al. BMC Medical Genetics 2008 9:37   doi:10.1186/1471-2350-9-37

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