|
Summary of linkage scan on chromosome 15q14-22.1 |
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| Population |
Sample |
Score |
Phenotype |
STS marker |
Position (cM) |
References (year) |
|
|
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| Japanese |
224 ASP in 159 families, 359 individuals |
1.57 MLS |
T2D |
D15S994 |
40.25 |
Mori Y et al. 2002 [11] |
| 3.91 MLS |
T2D (Young-onset < 45) |
D15S994 |
40.25 |
|||
| 2.44 MLS |
T2D (BMI < 30) |
D15S994 |
40.25 |
|||
| 1.50 MLS |
T2D |
D15S118 |
32.58 |
|||
| 0.95 MLS |
T2D |
D15S117 |
51.21 |
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| Japanese |
256 ASP in 164 families, 368 individuals |
2.41 LOD |
T2D (BMI < 22) |
CYP19 |
45.62 |
Iwasaki N et al. 2003 [12] |
| Japanese |
102 ASP in 102 families |
0.25 LOD |
T2D |
D15S117 |
51.21 |
Nawata H et al. 2004 [13] |
|
|
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| Mexican Americans |
330 ASP in 170 families, 408 individuals |
1.50 MLS |
T2D |
D15S119 |
45.62 |
Hanis CL et al. 1996 [14] |
| Pima Indians |
388 ASP in 109 families, 363 individuals |
1.46 LOD |
insulin secretion (IVGTT 10) |
D15S659 |
43.47 |
Pratley RE et al. 1998 [15] |
| Mexican Americans |
330 ASP in 170 families and 363 nondiabetic individuals |
1.27 LOD |
T2D |
D15S119 |
45.62 |
Cox NJ et al. 1999 [16] |
| interaction with D15S119 and CYP19 |
4.00 LOD |
T2D |
D15S119+ CYP19 |
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|
ASP, affected sib-pairs; MLS, maximum lod score; LOD, logarithm of odds; IVGTT 10, plasma insulin response at 10 min above the basal level during the intravenous glucose tolerance test; D15S119 + CYP19, D15S119 interaction with CYP19 (NIDDM1). Each report identified nominal evidence of linkage or significant evidence of linkage with LOD > 3.91. Location is shown only for loci with positive evidence of linkage on chromosome 15q. The position is based on the Marshfield recombination genetic map . http://research.marshfieldclinic.org/genetics/Home/index.asp | ||||||
Yamaguchi et al. BMC Medical Genetics 2008 9:22 doi:10.1186/1471-2350-9-22 |
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