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Dysregulated genes from patients in relapse and remission encoded in genomic regions associated with MS. |
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| Chromosomal Region Associated with MS |
Genes Upregulated in Relapse |
Genes Downregulated in Relapse |
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| 5q331 |
SOX30 |
0 |
| 17q231 |
FTSJ3, USP32, MRC2, TLK2, PRKAR1A |
SMARCD2, HAN11WD |
| 19p131 |
CD97, HOMER3, THRAP5, ILF3, OAZ1, AES, FUTC, SAFB, C19ORF6, ARHGEF18, SF4, GADD45B, CYP4F12 |
RGS19IP1, DHPS, MGC11271, KLF1, GCDH, FLJ90396, AZU1, FARSLA, KHSRP, TRIP10, ILVB1, ANGPTL4, NDUB7, NDUFA, MADCAM17 |
| 11q23 (D11S1986) 2 |
0 |
0 |
| 19q13.2 (D19S552) 2 |
TGFB1, CEACAM1, GMF |
0 |
| 20p12 (D20S894) 2 |
0 |
0 |
| IMSGC3 |
TAF1A |
FHIT, DBC1 |
|
|
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| Genes Upregulated in Remission |
Genes Downregulated in Remission |
|
|
|
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| 5q331 |
0 |
0 |
| 17q231 |
0 |
0 |
| 19p131 |
0 |
0 |
| 11q23 (D11S1986) 2 |
SDHD, CASP1, SIAT4C, APLP2 |
MGC2574, CD3E, RARRES3, CD3G, MTVR1, PCSK7 |
| 19q13.2 (D19S552) 2 |
CEACAM4, VASP |
PSG6, HNRPUL1, PVR, EIF3S12 |
| 20p12 (D20S894) 2 |
0 |
0 |
| IMSGC3 |
CD58 |
FHIT |
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Chromosomal regions are those identified as associated by Sawcer et al (2005)1 [27] from the family study or by the GAMES collaboration (2006)2 [26] using microsatellites (as marked) in a case/control study, and from the IMSGC SNP based genome wide analysis3 [10]. Genes are from the set of genes dysregulated in relapse and remission. Highlighted genes have been associated with MS in replication cohorts. | ||
Arthur et al. BMC Medical Genetics 2008 9:17 doi:10.1186/1471-2350-9-17 |
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