Table 1

GO pathways over-represented in the relapse and remission upregulated gene sets.

Disease Phase/Expression
Gene Ontology
p-value
Genes

RELAPSE Upregulated
GO:0009607 – Response to biotic stimulus
0.0462
GPR65, NMI, TAP2, IFI16, CSF2RB, TCRIM, ICOS, FCGR2B, CD48, BST1, TNFSF10, TLR5, MCP, DNAJB6, MNDA, GBP2, OXSR1, AQP9, TNFAIP6, NFIL3, CD53, GEM, LY96, DOCK2, IL1B, CLECSF6, PARP4, PLA2G7, CD97, MX2, 5233, HSPA1B, MAPK14, IL1R2, C3AR1, IFIT2, STAT1, IFNGR1, S100A8, EDEM1, LYZ, FAS, HSPA1L, LTBR, IL1RL1, B2M, HSPA1A

GO:0008219 – Cell death
0.0462
PARP4, GADD45B, MCL1, BCL2, GPR65, SMNDC1, RAF1, BIRC2, RAD21, CASP3, CASP10, TXNL1, BCLAF1, API5, STAT1, CUL1, YWHAG, TNFSF10, GADD45G, LYZ, FAS, IL1B, TRAF5, LTBR, TAX1BP1, CASP1, BID

GO:0006955 – Immune response
0.0462
GPR65, NMI, TAP2, IFI16, CSF2RB, TCRIM, ICOS, FCGR2B, BST1, TNFSF10, TLR5, MCP, MNDA, GBP2, AQP9, NFIL3, TNFAIP6, CD53, GEM, DOCK2, LY96, IL1B, CLECSF6, PARP4, PLA2G7, CD97, MX2, MAPK14, IL1R2, C3AR1, IFIT2, S100A8, FAS, LTBR, IL1RL1, B2M

GO:0016265 – Death
0.0462
PARP4, GADD45B, MCL1, BCL2, GPR65, SMNDC1, RAF1, BIRC2, RAD21, CASP3, CASP10, TXNL1, BCLAF1, API5, STAT1, CUL1, YWHAG, TNFSF10, GADD45G, LYZ, FAS, IL1B, TRAF5, LTBR, TAX1BP1, CASP1, BID

GO:0006952 – Defense response
0.0462
GPR65, NMI, TAP2, IFI16, CSF2RB, TCRIM, ICOS, FCGR2B, CD48, BST1, TNFSF10, TLR5, MCP, MNDA, GBP2, AQP9, NFIL3, TNFAIP6, CD53, GEM, DOCK2, LY96, IL1B, CLECSF6, PARP4, PLA2G7, CD97, MX2, MAPK14, IL1R2, C3AR1, IFIT2, S100A8, LYZ, FAS, LTBR, IL1RL1, B2M

GO:0004722 – Protein serine/threonine phosphatase activity
0.0462
MTMR6, PPM1A, PPM1B, DUSP6, PPP2R2A, MTMR1

GO:0006915 – Apoptosis
0.0462
GADD45B, MCL1, BCL2, GPR65, SMNDC1, RAF1, BIRC2, RAD21, CASP3, CASP10, TXNL1, BCLAF1, API5, STAT1, YWHAG, CUL1, TNFSF10, GADD45G, FAS, IL1B, TRAF5, LTBR, TAX1BP1, CASP1, BID

GO:0012501 – Programmed cell death
0.0462
GADD45B, MCL1, BCL2, GPR65, SMNDC1, RAF1, BIRC2, RAD21, CASP3, CASP10, TXNL1, BCLAF1, API5, STAT1, YWHAG, CUL1, TNFSF10, GADD45G, FAS, IL1B, TRAF5, LTBR, TAX1BP1, CASP1, BID

GO:0005057 – Receptor signaling protein activity
0.0533
STAT1, TGFBR2, RAF1, LYN, ACVR1B, MAPK14, NSMAF, MAPK9, IRS1, TCRIM, IL1RL1, PDLIM5, MAPK8
REMISSION Upregulated
GO:0015031- protein transport
0.0189
STXBP3, RANBP6, RAB2, PTTG1IP, ARF1, STX7, SNX2, GRP58, TLOC1, KPNB1, VDP, SNAG1, CLTC, COPB, TMED7, ARF3, RAB5A, TNPO1, RAB1A, COPA, RAB7, TLK1

GO:0045184 – establishment of protein localization
0.0189
STXBP3, RANBP6, RAB2, PTTG1IP, ARF1, STX7, SNX2, GRP58, TLOC1, KPNB1, VDP, SNAG1, CLTC, COPB, TMED7, ARF3, RAB5A, TNPO1, RAB1A, COPA, RAB7, TLK1

GO:0008104 – protein localization
0.0189
STXBP3, RANBP6, RAB2, PTTG1IP, ARF1, STX7, SNX2, GRP58, TLOC1, KPNB1, VDP, SNAG1, CLTC, COPB, TMED7, ARF3, RAB5A, TNPO1, RAB1A, COPA, RAB7, TLK1

GO:0005885 – Arp2/3 protein complex
0.046
ARPC2, ACTR3, ARPC3

GO:0030833 – regulation of actin filament polymerization
0.046
ARPC5, ARPC2, ARPC3

Arthur et al. BMC Medical Genetics 2008 9:17   doi:10.1186/1471-2350-9-17