Table 1

Specific methylation at Cytosine 8 & 20 in 31 human brain regions.

31 Brain Regions (originating from one individual) and Blood

mRNA expression

Methylation status of the Cytosines in 3 CpG dinucleotides (see Figure 1 for cytosine numbering)

Cytosine Number


3

8

20


Amygdala

Medium

○/●

○/●


BA5 Caudal Bank of Area 7

High

○/●

○/●


Corpus Callosum

NA

○/●

○/●


Cerebellum

High

○/●

○/●


Cerebellar Vermis

High

○/●

○/●


Hippocampus

NA

NA

○/●

○/●


Orbital Frontal Cortex

High

○/●

○/●


Putamen

Very low/absent

○/●

○/●


Temporal Lobe

NA

○/●

○/●


Thalamic Nucleus (Lateral)

NA

NA

○/●

○/●


White Cortical Matter

NA

NA

○/●

○/●


Cingulate Gyrus

Medium

○/●

○/●


Gray Cortical Matter

NA

○/●

○/●


Medulla Oblongata

High

○/●

○/●


Pons

Medium

○/●

○/●


Temporal Cortex (Inferior)

High

○/●

○/●


Visual Cortex (Occipital Pole)

High

○/●

○/●


Crus Cerebri Cerebral Peduncle

Very low/absent

○/●

○/●


Cingulate (Posterior Cortex)

High

○/●

○/●


Cingulate (Anterior Bilateral)

High

○/●

○/●


Cingulate (Anterior Cortex)

NA

○/●

○/●


Caudate (Head)

Very low/absent

○/●

○/●


Internal Capsule

Medium

○/●

○/●


Lentiform Nucleus (Posterior End)

Very low/absent

○/●

○/●


Red Nucleus (Bilateral)

Very low/absent

○/●

○/●


Thalamic Nucleus (Medial)

Very low/absent

○/●

○/●


Temporal Cortex (Superior)

Medium

○/●

○/●


Temporal Cortex (Medial)

High

○/●

○/●


Caudate Nucleus (Body)

Very low/absent

○/●

○/●


Internal Capsule (Posterior Limb)

NA

○/●

○/●


Thalamus (Lateral Geniculate Nucleus)

NA

○/●

○/●


Blood (from table 1)

NA

○/●

○/●or ●


● methylated, ○ unmethylated, ○/● partial methylation and NA not available.

Murphy et al. BMC Medical Genetics 2008 9:115   doi:10.1186/1471-2350-9-115

Open Data