Table 2

Top genetic association and linkage results

2a – Top association results from population-based association tests


Phenotype

SNP

Chr

Physical Position

GEE p-value

FBAT p-value

Gene Region


Sleepiness

rs1823068

5

58,711,806

2.5*10-8

.069

PDE4D

Sleepiness

rs2218488

8

72,426,510

3.2*10-6

.070

EYA1

Sleepiness

rs2247614

21

35,553,557

.000011

.0045

Sleepiness

rs7073579

10

1,364,007

.000014

.0081

ADARB2

Sleepiness

rs9298693

9

13,891,409

.000016

.28

Bedtime

rs949175

11

97,242,217

9.7*10-6

.38

Bedtime

rs2288292

11

12,452,275

.000017

.0096

PARVA

Bedtime

rs324981

7

34,591,353

.000018

.089

NPSR1

Bedtime

rs10483871

14

75,141,034

.000045

.0065

C14orf58

Bedtime

rs10507551

13

46,659,884

.000048

.032

Sleep duration

rs6599077*

3

40,071,622

1.4*10-7

.020

MYRIP

Sleep duration

rs10492604

13

57,802,314

4.2*10-6

.038

Sleep duration

rs10489832

1

155,267,429

.000028

.0043

OR10K1, OR10K2

Sleep duration

rs2256551

20

51,066,908

.000065

.11

TSHZ2

Sleep duration

rs2165207

12

72,418,535

.000011

.13


2b – Top association results from family-based association tests


Phenotype

SNP

Chr

Physical Position

GEE p-value

FBAT p-value

Gene Region


Sleepiness

rs10510835

3

60,222,161

.00054

.000019

FHIT

Sleepiness

rs2189829

7

49,387,124

.53

.000019

Sleepiness

rs434052*

14

35,613,399

.0024

.000024

Sleepiness

rs4896580

6

142,518,529

.000096

.000056

VTA1

Sleepiness

rs10520010

4

150,482,987

.013

.000064

Bedtime

rs1940013*

11

131,786,861

.0026

6.1*10-6

OPCML

Bedtime

rs2525724

7

120,203,894

.33

.000019

ING3

Bedtime

rs1725021

7

136,350,575

.031

.000022

PTN

Bedtime

rs932650

10

115,337,349

.37

.000025

HABP2

Bedtime

rs2985334

1

29,165,643

.0099

.000035

EPB41

Sleep duration

rs481233

6

126207158

.85

.000072

NCOA7

Sleep duration

rs2359894

18

40309270

.059

.00011

Sleep duration

rs2061579

12

73224522

.13

.00014

Sleep duration

rs10492507

13

48722291

.037

.00021

CDADC1

Sleep duration

rs6974138

7

74708138

.20

.00024


2c – Linkage peaks with LOD score >2.0


Phenotype

SNP closest to linkage peak

Chr

Physical location of linkage peak

Maximum LOD score

1.5 LOD support interval (Mb)


Bedtime

rs28168

16

55,508,777

2.45

48.5 – 62.0

Bedtime

rs10498313

14

29,468,627

2.33

28.7 – 32.6

Bedtime

rs10503857

8

29,909,250

2.26

21.9 – 37.1

Bedtime

rs10512058

9

76,736,108

2.11

10.6 – 107.4


*A second strongly associated SNP in this gene region is not reported in the table because it is in close proximity to and in linkage disequilibrium (D' 1.0) with the reported SNP.

Gottlieb et al. BMC Medical Genetics 2007 8(Suppl 1):S9   doi:10.1186/1471-2350-8-S1-S9

Open Data