Table 4 |
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|
Candidate gene evaluation |
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|
Gene region |
Chr |
SNP |
Phenotype |
FBAT p-value |
GEE p-value |
|
|
|||||
|
Alpha-1-antitrypsin (AAT/SERPINA1) |
14 |
rs2402446 rs10484042 |
ppfvc fev1slope |
0.02 0.90 |
0.30 0.01 |
|
Beta-2 adrenergic receptor (ADRB2) |
5 |
rs30329 rs9325117 |
fefslope meanratio |
0.009 - |
0.07 0.04 |
|
cystic fibrosis transmembrane regulator (CFTR) |
7 |
rs213987 rs10487367 |
meanfvc ppratio |
0.006 0.25 |
0.38 0.002 |
|
Microsomal epoxide hydrolase (EPHX1) |
1 |
rs3738051 |
fefslope ppfefrat |
0.01 0.03 |
0.30 0.04 |
|
Vitamin D binding protein (GC) |
4 |
rs423817 rs842873 |
ppfefrat ppfefrat |
0.0009 0.05 |
0.06 0.02 |
|
Glutathione S-transferase M2 (GSTM2) |
1 |
rs542338 |
meanratio fev1slope |
0.19 0.43 |
0.63 0.20 |
|
Glutathione S-transferase O2 (GSTO2) |
10 |
rs156697 |
meanfvc |
9.4 × 10-05 |
9.8 × 10-06 |
|
Glutathione S-transferase P1 (GSTP1) |
11 |
rs688878 |
ppfefrat ppfvc |
0.07 0.39 |
0.35 0.02 |
|
Glutathione S-transferase T2 (GSTT2) |
22 |
rs140289 |
ppfvc ppfev1 |
0.17 0.41 |
0.13 0.10 |
|
Heme oxygenase (HMOX1) |
22 |
rs2267331 rs10483190 |
fev1slope meanratio |
0.07 0.82 |
0.80 0.008 |
|
Interleukin-10 (IL10) |
1 |
rs10494879 |
fefslope fev1slope |
0.06 0.46 |
0.73 0.02 |
|
Matrix metalloproteinase-1 (MMP1) |
11 |
rs495366 |
fefslope ppfef |
0.02 0.20 |
0.13 0.03 |
|
Matrix metalloproteinase-9 (MMP9) |
20 |
rs2903908 |
ppfefrat |
0.19 |
0.05 |
|
Alpha-1-antichymotrypsin (SERPINA3) |
14 |
rs10484047 |
ppfvc fev1slope |
0.02 0.10 |
0.03 0.01 |
|
Serine proteinase inhibitor E2 (SERPINE2) |
2 |
rs717610 |
meanfvc meanratio |
0.04 0.19 |
0.003 0.001 |
|
Surfactant protein B (SFTPB) |
2 |
rs7577293 |
meanratio |
0.02 |
0.06 |
|
Surfactant protein D (SFTPD) |
10 |
rs726289 |
fefslope |
0.02 |
0.03 |
|
extracellular super oxide dismutase (SOD3) |
4 |
rs10489030 |
ppfev1 ppfvc |
0.0005 0.01 |
0.02 0.007 |
|
transforming growth factor beta-1 (TGFB1) |
19 |
rs3745295 |
fev1slope ppfev1 |
0.21 0.74 |
0.62 0.18 |
|
Tissue inhibitor of metalloproteases-2 (TIMP2) |
17 |
rs2889529 |
ppfef meanratio |
0.07 0.18 |
0.11 0.09 |
|
|
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|
Best p-value for FBAT and GEE tests reported with specific SNP*phenotype producing result. P-values < 0.01 bolded. |
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|
Wilk et al. BMC Medical Genetics 2007 8(Suppl 1):S8 doi:10.1186/1471-2350-8-S1-S8 |
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