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Phenotypic Associations With Candidate Genes Previously Related To Stroke, Dementia And Brain MRI Or Cognitive Function Phenotypes: Phenotype-SNP Associations With A GEE Or FBAT P-Value < 0.001 |
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| Gene |
Phenotype |
SNP |
Chr |
Physical Position |
GEE_Pvalue |
FBAT_Pvalue |
|
|
||||||
| NGFB |
AHPV |
rs10489531 |
1 |
115495044 |
9.7 × 10-4 |
0.046 |
| PRSS25 |
ATBV |
rs363685 |
2 |
74726491 |
2.5 × 10-4 |
|
| ATCBV |
rs363685 |
2 |
74726491 |
5.7 × 10-5 |
||
| GRK4 |
F1 |
rs2105380 |
4 |
3019934 |
0.276 |
5.8 × 10-4 |
| HMGE |
ATBV |
rs4689584 |
4 |
7179291 |
0.035 |
1.0 × 10-4 |
| APBB2 |
F1 |
rs10517001 |
4 |
41051593 |
1.4 × 10-4 |
0.009 |
| SNCA |
Sim |
rs3796661 |
4 |
91044685 |
2.6 × 10-4 |
0.332 |
| AHPV |
rs2870028 |
4 |
91122391 |
3.2 × 10-4 |
0.180 |
|
| AHPV |
rs7678651 |
4 |
91125549 |
1.3 × 10-4 |
0.102 |
|
| AHPV |
rs10516848 |
4 |
91132390 |
1.6 × 10-4 |
0.115 |
|
| PDE4D |
WRAT |
rs295973 |
5 |
58945866 |
5.3 × 10-4 |
0.060 |
| Sim |
rs10514882 |
5 |
59170282 |
6.4 × 10-5 |
||
| Sim |
rs9292216 |
5 |
59187886 |
2.4 × 10-4 |
||
| DCDC2 |
F3 |
rs10484657 |
6 |
24224829 |
0.017 |
9.5 × 10-4 |
| ATCBV |
rs10484657 |
6 |
24224829 |
6.0 × 10-4 |
0.015 |
|
| THBS2 |
ATBV |
rs6937001 |
6 |
169382718 |
6.0 × 10-4 |
0.021 |
| GATA4 |
WRAT |
rs7006733 |
8 |
11645399 |
0.034 |
3.1 × 10-4 |
| NRG1 |
ATCBV |
rs1383893 |
8 |
31844190 |
0.407 |
8.9 × 10-4 |
| F2 |
rs10503906 |
8 |
32291504 |
0.187 |
4.2 × 10-4 |
|
| AFBV |
rs10503919 |
8 |
32519284 |
1.9 × 10-4 |
0.288 |
|
| BMRIZLWMH |
rs10503926 |
8 |
32660758 |
8.7 × 10-5 |
0.009 |
|
| VMV |
rs10503927 |
8 |
32662772 |
2.0 × 10-4 |
0.002 |
|
| VLDLR |
ATCBV |
rs502309 |
9 |
2562909 |
5.4 × 10-6 |
0.157 |
| Nam |
rs2168136 |
9 |
2584577 |
1.6 × 10-4 |
0.006 |
|
| NTRK2 |
F1 |
rs10512152 |
9 |
84457363 |
7.6 × 10-5 |
0.018 |
| AFBV |
rs1573219 |
9 |
84617176 |
0.174 |
5.6 × 10-4 |
|
| AFBV |
rs7038866 |
9 |
84617461 |
0.146 |
3.6 × 10-4 |
|
| TEK |
ATBV |
rs628873 |
9 |
27162838 |
4.9 × 10-4 |
0.051 |
| BACE1 |
APBV |
rs1261791 |
11 |
116705848 |
0.021 |
3.1 × 10-4 |
| SORL1 |
Sim |
rs1131497 |
11 |
121007955 |
0.008 |
3.2 × 10-6 |
| Sim |
rs726601 |
11 |
120986617 |
0.046 |
8.2 × 10-4 |
|
| VWF |
ATCBV |
rs216903 |
12 |
5975760 |
0.149 |
9.5 × 10-4 |
| A2M |
F3 |
rs2889717 |
12 |
9178068 |
9.3 × 10-5 |
|
| LRRK2 |
WRAT |
rs2249017 |
12 |
38847487 |
5.5 × 10-4 |
0.061 |
| F1 |
rs7975693 |
12 |
38874945 |
8.1 × 10-5 |
0.005 |
|
| AFBV |
rs10506151 |
12 |
38957265 |
3.7 × 10-4 |
1.6 × 10-4 |
|
| ATBV |
rs10506151 |
12 |
38957265 |
9.7 × 10-4 |
0.371 |
|
| CNTN1 |
ATBV |
rs10506176 |
12 |
39561067 |
8.8 × 10-4 |
0.622 |
| LTA4H |
Sim |
rs10492226 |
12 |
94906457 |
6.7 × 10-4 |
|
| IGF1 |
ALLV |
rs1980236 |
12 |
101270359 |
0.046 |
9.3 × 10-4 |
| LTB4R2 |
APBV |
rs724165 |
14 |
23876069 |
4.5 × 10-4 |
0.162 |
| NTRK3 |
ALLV |
rs10520671 |
15 |
86347520 |
6.2 × 10-5 |
0.062 |
| CCL2 |
WRAT |
rs1024612 |
17 |
29573469 |
0.231 |
7.0 × 10-4 |
| PRKCA |
F1 |
rs9303511 |
17 |
62158093 |
0.068 |
7.9 × 10-4 |
| CST3 |
AOBV |
rs1158167 |
20 |
23526189 |
6.5 × 10-4 |
0.032 |
| PRNP |
APBV |
rs2326510 |
20 |
4649211 |
0.000718 |
0.064794 |
| BACE2 |
F1 |
rs2007397 |
21 |
41438062 |
0.030 |
2.2 × 10-4 |
| F1 |
rs10483073 |
21 |
41499167 |
3.5 × 10-4 |
||
| Nam |
rs10483073 |
21 |
41499167 |
1.7 × 10-4 |
||
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*Genes in bold are highlighted in discussion section. | ||||||
Seshadri et al. BMC Medical Genetics 2007 8(Suppl 1):S15 doi:10.1186/1471-2350-8-S1-S15 |
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