Table 5

Associations achieving nominal genome wide significance, p < 5*10^-8 across the 17 phenotype working groups

Phenotype working group/manuscript

Trait

SNP rs ID*

Chr

Physical location (bp)

GEE P-value

FBAT P-value

IN/NEAR gene

Select biomarkers [33]

Monocyte chemoattractant protein-1

rs2494250

1

156,091,324

1.0*10^-14

3.5*10^-8

FCER1A, OR10J3

Monocyte chemoattractant protein-1

rs4128725

1

156,219,032

3.7*10^-12

3.3*10^-8

OR10J1

C-reactive protein average exams 2,6,7

rs2794520

1

156,491,889

2.8*10^-8

4.3*10^-5

CRP

C-reactive protein average exams 2,6,7

rs2808629

1

156,489,869

3.2*10^-8

4.8*10^-5

CRP

Kidney/Endocrine [42]

Cystatin C

rs1158167

20

23,526,189

8.5*10^-09

0.006

CST9L|CST9|CST3

Diabetes [38]

28-year mean fasting plasma glucose

rs2722425

8

40,603,396

2.0*10^-8

0.005

ZMAT4

Sleep and circadian [26]

Epworth sleepiness scale

rs1823068

5

58,711,806

2.5*10^-8

0.069

PDE4D

Neurology [37]

Total Cerebral Brain Volume (ATCBV)

rs1970546

20

59287333

4.0*10^-8

0.005

CDH4

Hemostatic factors [34]

Factor VII

rs561241

13

112,808,035

4.5*10^-16

3.4*10^-4

F7

The following phenotype working groups did not have any traits achieving nominal genome-wide significance: echocardiography, flow-mediated dilation and exercise tolerance testing; blood pressure and tonometry; subclinical cardiovascular disease; cardiovascular outcomes; cancer; electrocardiography and heart rate variability; pulmonary function testing; aging; bone; lipids; obesity

Cupples et al. BMC Medical Genetics 2007 8(Suppl 1):S1   doi:10.1186/1471-2350-8-S1-S1