Open Access Research article

Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample

Rebecca L Pollex1, Matthew R Ban1, T Kue Young2, Peter Bjerregaard3, Sonia S Anand4, Salim Yusuf4, Bernard Zinman5, Stewart B Harris6, Anthony JG Hanley57, Philip W Connelly8, Murray W Huff19 and Robert A Hegele19*

Author Affiliations

1 Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada

2 Department of Public Health Sciences, University of Toronto, Ontario, Canada

3 National Institute of Public Health, Copenhagen, Denmark

4 Population Health Research Institute, McMaster University, Hamilton Health Sciences, Hamilton, Ontario, Canada

5 Department of Medicine, University of Toronto, and Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada

6 Thames Valley Family Practice Research Unit, University of Western Ontario, London, Ontario, Canada

7 Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada

8 Department of Laboratory Medicine and Pathobiology, University of Toronto, and the Keenan Research Centre, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada

9 Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

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BMC Medical Genetics 2007, 8:80  doi:10.1186/1471-2350-8-80

Published: 20 December 2007

Additional files

Additional file 1:

Supplementary Tables. Six supplementary tables including: Table S1. Clinical and biochemical data of subjects. Table S2. Clinical and biochemical data of subjects when classified in accordance to their genotype of the APOC3 -455T>C polymorphism. Table S3. Genotype and allele frequencies for the APOC3 -455T>C polymorphism in subjects with and without MetS. Table S4. Clinical and biochemical data of subjects when classified in accordance to their genotype of the INSIG2 rs7566605 G>C polymorphism. Table S5. Genotype and allele frequencies for the INSIG2 rs7566605 G>C polymorphism in subjects with and without MetS. Table S6. Greenland Inuit plasma apo C-III concentration, by APOC3 -455T>C genotype

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