TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

doi:10.1186/1471-2350-8-37

BMC Medical Genetics

Volume 8

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Cauchi S
Meyre D
Choquet H
Deghmoun S
Durand E
Gaget S
Lecoeur C
Froguel P
Levy-Marchal C

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Meyre D
Choquet H
Deghmoun S
Durand E
Gaget S
Lecoeur C
Froguel P
Levy-Marchal C
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Research article

TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

Stéphane Cauchi¹ , David Meyre¹ , Hélène Choquet¹ , Samia Deghmoun² , Emmanuelle Durand¹ , Stefan Gaget¹ , Cécile Lecoeur¹ , Philippe Froguel¹^,3 and Claire Levy-Marchal²

¹CNRS, 8090-Institute of biology, Pasteur Institute, Lille, 59000 France

²INSERM, U690, Robert Debré Hospital, Paris, 75019 France

³Genomic Medicine, Hammersmith Hospital, Imperial College London, UK

author email corresponding author email

BMC Medical Genetics 2007, 8:37doi:10.1186/1471-2350-8-37


Published:	25 June 2007

Abstract

Background

In adults, the TCF7L2 rs7903146 T allele, commonly associated with type 2 diabetes (T2D), has been also associated with a lower body mass index (BMI) in T2D individuals and with a smaller waist circumference in subjects with impaired glucose tolerance.

Methods

The present association study aimed at analyzing the contribution of the rs7903146 SNP to smallness for gestational age (SGA) and metabolic profiles in subjects with SGA or appropriate for gestational age birth weight (AGA). Two groups of French Caucasian subjects were selected on birth data: SGA (birth weight < 10^thpercentile; n = 764), and AGA (25^th< birth weight < 75^thpercentile; n = 627). Family-based association tests were also performed in 3,012 subjects from 628 SGA and AGA pedigrees.

Results

The rs7903146 genotypic distributions between AGA (30.7%) and SGA (29.0%) were not statistically different (allelic OR = 0.92 [0.78–1.09], p = 0.34). Family association-based studies did not show a distortion of T allele transmission in SGA subjects (p = 0.52). No significant effect of the T allele was detected on any of the metabolic parameters in the SGA group. However, in the AGA group, trends towards a lower insulin secretion (p = 0.03) and a higher fasting glycaemia (p = 0.002) were detected in carriers of the T allele.

Conclusion

The TCF7L2 rs7903146 variant neither increases the risk for SGA nor modulates birth weight and young adulthood glucose homeostasis in French Caucasian subjects born with SGA.