Three allele combinations associated with Multiple Sclerosis

doi:10.1186/1471-2350-7-63

BMC Medical Genetics

Volume 7

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Favorova OO
Favorov AV
Boiko AN
Andreewski TV
Sudomoina MA
Alekseenkov AD
Kulakova OG
Gusev EI
Parmigiani G
Ochs MF

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Favorova OO
Favorov AV
Boiko AN
Andreewski TV
Sudomoina MA
Alekseenkov AD
Kulakova OG
Gusev EI
Parmigiani G
Ochs MF
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Research article

Three allele combinations associated with Multiple Sclerosis

Olga O Favorova¹^,2 , Alexander V Favorov³ , Alexey N Boiko⁴ , Timofey V Andreewski² , Marina A Sudomoina¹^,2 , Alexey D Alekseenkov² , Olga G Kulakova¹ , Eugenyi I Gusev⁴ , Giovanni Parmigiani⁵ and Michael F Ochs⁶

¹Department of Molecular Biology and Medical Biotechnology, Russian State Medical University, 15 3d Cherepkovskaya ul., Moscow 121552, Russia

²Cardiology Research Center, 15 3d Cherepkovskaya ul., Moscow 121552, Russia

³Bioinformatics Laboratory, GosNIIGenetika, 1 1st Dorozhny pr., Moscow 117545, Russia

⁴Department of Neurology and Neurosurgery, Russian State Medical University, 1 Ostrovitianova ul., Moscow 117997, Russia

⁵Departments of Oncology, Pathology and Biostatistics, Johns Hopkins University, 550 North Broadway, s. 1103, Baltimore, Maryland 21205, USA

⁶Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, USA

author email corresponding author email

BMC Medical Genetics 2006, 7:63doi:10.1186/1471-2350-7-63


Published:	26 July 2006

Additional files

Additional File 1:

Additional Figure 1 – TNFa/TNFb haplotype frequencies in MS patients and controls . Haplotypes are designated in accordance with TNFa/TNFb allele names.

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Additional File 2:

Additional Figure 2 – DRB1/TNFa haplotype frequencies in MS patients and controls . A: DRB1*01 -DRB1*03 alleles; B: DRB1*04 -DRB1*09 alleles. Haplotypes are designated in accordance with DRB1/TNFa allele names. Haplotypes with frequencies less than 0.5% both in MS patients and in controls are not shown.

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Additional File 3:

Additional Figure 3 – TNF/LT haplotypes in MS patients and controls. A: TNF/LT haplotype frequencies in all MS patients and controls; haplotype designations and entering SNP alleles are shown below. B: Frequencies of extended haplotypes including DRB1*15(2) and different TNF/LT haplotypes in all MS patients and controls. Haplotypes are marked in accordance with DRB1 allele name and TNF/LT haplotype designation given in A. For better visualization, the same axis scales were used.

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Additional File 4:

Additional Table 1 – Phenotypic frequencies (%) of SNP alleles in Russian MS patients and healthy individuals

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