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Marginal Means for Traits Associated with Betacellulin Polymorphisms in Non-diabetic Individuals |
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| Variant |
Trait |
Major/Major |
Major/Minor |
Minor/Minor |
p value |
|
|
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| C7G |
triglycerides mmol/l |
1.343 (1.131, 1.556) |
1.025 (0.881, 1.169) |
0.865 (0.653, 1.078) |
0.007 |
| C7G |
HDL cholesterol mmol/l |
1.372 (1.229, 1.515) |
1.280 (1.183, 1.377) |
1.536 (1.392, 1.679) |
0.015 |
| L44F |
triglycerides mmol/l |
0.953 (0.853, 1.066) |
1.174 (0.853, 1.066) |
--- |
0.059 |
| L124M |
cholesterol mmol/l |
4.675 (4.400, 4.951) |
4.2551 (3.967, 4.544) |
--- |
0.038 |
|
Marginal means are shown after correction for age, gender, and body mass index for each genotype. For C7G, 26 major homozygotes, 54 heterozygotes, and 25 minor homozygotes were successfully typed. For L44P, we identified 60 homozygotes and 21 heterozygotes (no minor homozygotes observed). For L124M, we identified 57 major homozygotes, 45 heterozygotes, and 4 minor homozygous individuals. 1 Data are shown for Major/Minor + Minor/Minor combined. Lipid data are all in mmol/l. We provide means and 95% confidence intervals, converted to the linear scale for skewed variables. P values are for comparison of genotypes shown in the table, taken from the mixed effects model. | |||||
Elbein et al. BMC Medical Genetics 2006 7:62 doi:10.1186/1471-2350-7-62 |
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