Table 4

Pooled differences (95% CI) in body mass index (kg/m2) between individuals homozygous and heterozygous carriers of the 363S allele of the GRL gene and homozygotes for the N363 allele. Fixed effects model

Studies

Difference in BMI (kg/m2) Pooled estimates

95% CI

Q statistic

k

p#


Overall studies

+0.18

+0.004 to +0.35*

84.47

21

<0.0001

BMI < 27 kg/m2

+0.14

-0.052 to +0.32

29.15

10

0.0006

BMI > 27 kg/m2

+0.37

-0.047 to +0.79

54.31

11

<0.0001

Adults (>25 years)

+0.51

+0.31 to +0.72*

27.47

16

0.0252

Children and adolescents (<25 years)

-0.67

-0.99 to -0.35*

19.94

5

0.0005

- Ethnicity

European Countries

+0.16

-0.01 to +0.34

74.84

15

<0.0001

Australia

+0.45

-0.34 to +1.24

9.03

5

0.06

- Gender

Men

-0.37

-1.25 to +0.51

1.20

3

0.5487

Men and women

+0.20

+0.02 to +0.37

81.76

18

<0.0001

- Mutation prevalence

(<5%)

-0.54

-0.96 to -0.12

20.69

6

0.0009

(5–10%)

+0.34

+0.15 to +0.54

37.74

9

<0.0001

(>10%)

+0.10

-0.57 to +0.77

11.84

6

0.037

One population

BMI < 27 kg/m2

+0.41

+0.17 to +0.66*

5.88

4

0.1177

BMI ≥ 27 kg/m2

+1.19

+0.64 to +1.74*

13.34

5

0.0097

Normal weight subjects

already published data

+0.56

-0.07 to +1.19

1.04

3

0.5941

novel data

-0.50

-0.84 to -0.17*

1.72

3

0.4227

Obese subjects

already published data

+0.32

-0.82 to +1.46

0.07

3

0.9633

novel data

-1.26

-2.10 to -0.49*

15.77

3

<0.001


k: number of studies;

# test for heterogeneity;

* p < 0.05 for the pooled difference in BMI.

Marti et al. BMC Medical Genetics 2006 7:50   doi:10.1186/1471-2350-7-50

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