|
Pooled differences (95% CI) in body mass index (kg/m2) between individuals homozygous and heterozygous carriers of the 363S allele of the GRL gene and homozygotes for the N363 allele. Fixed effects model |
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| Studies |
Difference in BMI (kg/m2) Pooled estimates |
95% CI |
Q statistic |
k |
p# |
|
|
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| Overall studies |
+0.18 |
+0.004 to +0.35* |
84.47 |
21 |
<0.0001 |
| BMI < 27 kg/m2 |
+0.14 |
-0.052 to +0.32 |
29.15 |
10 |
0.0006 |
| BMI > 27 kg/m2 |
+0.37 |
-0.047 to +0.79 |
54.31 |
11 |
<0.0001 |
| Adults (>25 years) |
+0.51 |
+0.31 to +0.72* |
27.47 |
16 |
0.0252 |
| Children and adolescents (<25 years) |
-0.67 |
-0.99 to -0.35* |
19.94 |
5 |
0.0005 |
| - Ethnicity |
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| European Countries |
+0.16 |
-0.01 to +0.34 |
74.84 |
15 |
<0.0001 |
| Australia |
+0.45 |
-0.34 to +1.24 |
9.03 |
5 |
0.06 |
| - Gender |
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| Men |
-0.37 |
-1.25 to +0.51 |
1.20 |
3 |
0.5487 |
| Men and women |
+0.20 |
+0.02 to +0.37 |
81.76 |
18 |
<0.0001 |
| - Mutation prevalence |
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| (<5%) |
-0.54 |
-0.96 to -0.12 |
20.69 |
6 |
0.0009 |
| (5–10%) |
+0.34 |
+0.15 to +0.54 |
37.74 |
9 |
<0.0001 |
| (>10%) |
+0.10 |
-0.57 to +0.77 |
11.84 |
6 |
0.037 |
| One population |
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| BMI < 27 kg/m2 |
+0.41 |
+0.17 to +0.66* |
5.88 |
4 |
0.1177 |
| BMI ≥ 27 kg/m2 |
+1.19 |
+0.64 to +1.74* |
13.34 |
5 |
0.0097 |
| Normal weight subjects |
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| already published data |
+0.56 |
-0.07 to +1.19 |
1.04 |
3 |
0.5941 |
| novel data |
-0.50 |
-0.84 to -0.17* |
1.72 |
3 |
0.4227 |
| Obese subjects |
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| already published data |
+0.32 |
-0.82 to +1.46 |
0.07 |
3 |
0.9633 |
| novel data |
-1.26 |
-2.10 to -0.49* |
15.77 |
3 |
<0.001 |
|
k: number of studies; # test for heterogeneity; * p < 0.05 for the pooled difference in BMI. | |||||
Marti et al. BMC Medical Genetics 2006 7:50 doi:10.1186/1471-2350-7-50 |
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