Table 2

Mean and difference (95% CI) in body mass index (kg/m2) between individuals homozygous and heterozygous carriers of the 363S allele of the GRL gene and homozygotes for the N363 allele in studies with two population group

Normal weight subjects
 Obese subjects
Study
 N363/363S 363S/363S
 N363/N363
 Mean difference
 95% CI
 % carriers
 N363/363S 363S/363S
 N363/N363
 Mean difference
 95% CI
 % carriers










n
 Mean BMI
 n
 Mean BMI



n
 Mean BMI
 n
 Mean BMI



Published data















Lin et al. 1999
 27
 26.5
 171
 25.7
 0.8
 -0.9
 2.5
 13.64
 39
 43.6
 107
 42.9
 0.7
 -2.5
 3.8
 26.71
Lin et al. 2003
 33
 26.6
 230
 25.6
 1.0
 -0.5
 2.5
 12.55
 39
 43.5
 111
 43.1
 0.4
 -2.7
 3.5
 26.00
Echwald et al. 2001
 79
 26.4
 775
 26.1
 0.2
 -0.6
 1.1
 9.25
 66
 35.9
 675
 35.7
 0.2
 -1.2
 1.7
 8.91
Total (n)
 139
1176




144
893




Novel data















Spain (Navarra)















Adults
 7
 22.4
 147
 22.3
 0.1
 -1.3
 1.4
 4.54
 2
 37.1
 157
 37.6
 -0.5
 -8.5
 7.5
 1.26
Children
 8
 18.6
 177
 18.9
 -0.3
 -2.2
 1.6
 4.32
 4
 24.3
 181
 27.6
 -3.3
 -7.9
 1.3
 2.16
Germany















Children and adolescents
 22
 17.6
 234
 18.3
 -0.7
 -1.2
 -0.2
 8.59
 8
 41.3
 170
 35.4
 5.9
 1.7
 10.2
 4.49
Total (n)
 37
558




14
508




In the study by Echwald et al (2001) only men were recruited from Copenhagen, Denmark, mean age = 45. The study by Lin et al (1999) included men (53%) and women (47%), mean age = 50, from Sydney (Australia), the study by Lin et al (2003) included men (80%) and women (20%), mean age = 45, from Sydney (Australia). The Navarra adults study enrolled men (20%) and women (80%), mean age = 40, from Navarra (North of Spain). The Navarra children study encompassed boys (53%) and girls (53%), mean age = 11 from Navarra (North of Spain). The German children study consisted of boys (50%) and girls (50%), mean age = 14 from West and South of Germany.

Marti et al. BMC Medical Genetics 2006 7:50   doi:10.1186/1471-2350-7-50