Table 2

Mean and difference (95% CI) in body mass index (kg/m²) between individuals homozygous and heterozygous carriers of the 363S allele of the GRL gene and homozygotes for the N363 allele in studies with two population group

Normal weight subjects

Obese subjects

Study

N363/363S 363S/363S

N363/N363

Mean difference

95% CI

% carriers

N363/363S 363S/363S

N363/N363

Mean difference

95% CI

% carriers

n

Mean BMI

n

Mean BMI

n

Mean BMI

n

Mean BMI

Published data

Lin et al. 1999

27

26.5

171

25.7

0.8

-0.9

2.5

13.64

39

43.6

107

42.9

0.7

-2.5

3.8

26.71

Lin et al. 2003

33

26.6

230

25.6

1.0

-0.5

2.5

12.55

39

43.5

111

43.1

0.4

-2.7

3.5

26.00

Echwald et al. 2001

79

26.4

775

26.1

0.2

-0.6

1.1

9.25

66

35.9

675

35.7

0.2

-1.2

1.7

8.91

Total (n)

139

1176

144

893

Novel data

Spain (Navarra)

Adults

7

22.4

147

22.3

0.1

-1.3

1.4

4.54

2

37.1

157

37.6

-0.5

-8.5

7.5

1.26

Children

8

18.6

177

18.9

-0.3

-2.2

1.6

4.32

4

24.3

181

27.6

-3.3

-7.9

1.3

2.16

Germany

Children and adolescents

22

17.6

234

18.3

-0.7

-1.2

-0.2

8.59

8

41.3

170

35.4

5.9

1.7

10.2

4.49

Total (n)

37

558

14

508

In the study by Echwald et al (2001) only men were recruited from Copenhagen, Denmark, mean age = 45. The study by Lin et al (1999) included men (53%) and women (47%), mean age = 50, from Sydney (Australia), the study by Lin et al (2003) included men (80%) and women (20%), mean age = 45, from Sydney (Australia). The Navarra adults study enrolled men (20%) and women (80%), mean age = 40, from Navarra (North of Spain). The Navarra children study encompassed boys (53%) and girls (53%), mean age = 11 from Navarra (North of Spain). The German children study consisted of boys (50%) and girls (50%), mean age = 14 from West and South of Germany.

Marti et al. BMC Medical Genetics 2006 7:50   doi:10.1186/1471-2350-7-50