Figure 2.

Diagram of alignment of human CLC-2 promoter and mammalian homologues (H = human, R = rat, M = mouse, GP = guinea pig, and Rb = rabbit. CLC-2 translation initiation site in all 5 species is denoted by "start". One single nucleotide polymorphism (SNP) is present at nt -693 (human). Hpol is a polymerase whose gene product is on the complementary strand, upstream from the CLC-2 promoter.