Table 2

Allelic and genotype frequencies of IL2/IL21, IL2RA and IL2RB genetic variants in uveitis patients and healthy controls from Spanish population
SNP 1/2 Subgroup (n) 11 12 22 MAF (%) Allelic P-value OR (95% CI)
IL2/IL21
rs2069762 C/A Controls (n=760) 61 (8.03) 315 (41.45) 384 (50.53) 437 (28.75)
Uveitis (n=195) 17 (8.71) 85 (43.60) 93 (47.69) 119 (30.51) 0.49 1.09 (0.85-1.40)
rs6822844 T/G Controls (n=760) 15 (1.97) 156 (20.53) 589 (77.50) 186 (12.24)
Uveitis (n=196) 2 (1.02) 28 (14.29) 166 (84.69) 32 (8.16) 0.02* 0.64 (0.43-0.94)
rs907715 T/C Controls (n=760) 81 (10.66) 330(43.42) 349(46.92) 492 (32.37)
Uveitis (n=196) 26 (13.27) 70 (35.71) 100 (51.02) 122 (31.12) 0.64 0.94 (0.74-1.20)
IL2RA
rs12722495 G/A Controls (n=760) 3 (0.39) 114 (15.00) 643 (84.61) 120 (7.90)
Uveitis (n=196) 2 (1.02) 29 (14.80) 165 (84.18) 33 (8.42) 0.73 1.07 (0.72-1.60)
rs2104286 C/T Controls (n=760) 19 (2.50) 270 (35.53) 471 (61.97) 308 (20.26)
Uveitis (n=196) 10 (5.10) 60(30.61) 126 (64.29) 80 (20.41) 0.95 1.01 (0.77-1.33)
rs11594656 T/A Controls (n=760) 84 (11.05) 346(45.53) 330(43.42) 514 (33.82)
Uveitis (n=196) 23 (11.79) 69 (35.38) 103 (52.82) 115 (29.49) 0.10 0.82 (0.64-1.04)
IL2RB
rs743777 G/A Controls (n=760) 86(11.32) 349(45.92) 325(42.76) 521 (34.28)
Uveitis (n=195) 26 (13.40) 72 (37.11) 96 (49.48) 124 (31.96) 0.39 0.90 (0.71-1.14)

*PFDR-corrected=0.17.

SNP; Single Nucleotide Polymorphism.

MAF; Minor Allele Frequency.

OR; Odds Ratio.

Cénit et al.

Cénit et al. BMC Medical Genetics 2013 14:52   doi:10.1186/1471-2350-14-52

Open Data