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Open Access Highly Accessed Research article

SOD2 gene Val16Ala polymorphism is associated with macroalbuminuria in Mexican Type 2 Diabetes patients: a comparative study and meta-analysis

Iván de Jesús Ascencio-Montiel1, Esteban J Parra2, Adán Valladares-Salgado1, Jaime H Gómez-Zamudio1, Jesús Kumate-Rodriguez3, Jorge Escobedo-de-la-Peña4 and Miguel Cruz1*

Author Affiliations

1 Biochemistry Research Unit, Hospital de Especialidades, Centro Médico Nacional “Siglo XXI”, Instituto Mexicano del Seguro Social, Mexico DF, Mexico

2 Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada

3 Fundación IMSS, Mexico DF, Mexico

4 Clinical Epidemiology Research Unit, Hospital General Regional No. 1 “Carlos MacGregor Sánchez Navarro”, Instituto Mexicano del Seguro Social, Mexico DF, Mexico

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BMC Medical Genetics 2013, 14:110  doi:10.1186/1471-2350-14-110

Published: 11 October 2013

Abstract

Background

Several studies in type 2 diabetes patients have shown significant associations between the SOD2 gene Val16Ala polymorphism and albuminuria, but this association has not been explored in the Mexican population.

Methods

We evaluated the association between the SOD2 gene Val16Ala polymorphism (rs4880) and macroalbuminuria in a sample of 994 unrelated Mexican type 2 diabetes patients. The study included 119 subjects with urinary albumin >300 mg/dL and 875 subjects with urinary albumin ≤ 30 mg/dL. Genotyping of the SOD2 gene Val16Ala SNP was carried out with Real-Time Polymerase Chain Reaction (RT-PCR).

Results

The frequency of the TT genotype was 6.7% higher in participants with macroalbuminuria than in the normoalbuminuria group (16.8% vs. 10.1%). Using a logistic regression analysis, we observed that individuals with the CC genotype had significantly lower risks of macroalbuminuria than those with the TT genotype (OR=0.42, p=0.034). We carried out a meta-analysis combining our data with data from four previous studies and estimated an odds ratio (95% CI) for the C allele (with respect to the reference T allele) of 0.65 (0.52-0.80, p<0.001).

Conclusions

A significant association was found between the SOD2 Val16Ala polymorphism and macroalbuminuria in a sample of Mexican type 2 diabetes patients.

Keywords:
Mexicans; Macroalbuminuria; SOD2; Type 2 diabetes; Val16Ala polymorphism