Table 2

Summary of different comparative results
Sample size No. of studies Test of association Heterogeneity
Polymorphisms Study Case Control OR (95% CI) Z P Value Model χ2 P Value I2 (%)
ApaI
AA vs. aa Overall 846 1048 11 1.47 (1.11-1.94) 2.66 0.008 R 13.03 0.220 23.0
aA vs. aa Overall 1059 1368 11 1.30 (1.06-1.60) 2.54 0.010 R 10.98 0.360 9.0
AA vs. aA Overall 1263 1290 11 1.04 (0.76-1.43) 0.25 0.810 R 26.31 0.003 62.0
AA + aA vs. aa Overall 1584 1853 11 1.34 (1.11-1.60) 3.12 0.002 R 7.49 0.680 0.0
AA + aA vs. aa Asian 1200 1468 7 1.43 (1.16-1.75) 4.57 <0.001 R 4.57 0.600 0.0
AA + aA vs. aa Caucasian 384 385 4 1.08 (0.74-1.57) 0.40 0.690 R 1.32 0.730 0.0
AA + aA vs. aa Hypercalciuria 295 262 4 1.24 (0.86-1.81) 1.15 0.250 R 3.10 0.380 3.0
AA + aA vs. aa Adult 1328 1148 8 1.30 (1.04-1.62) 2.33 0.020 R 3.99 0.780 0.0
AA + aA vs. aa HWE 1328 1148 8 1.30 (1.04-1.62) 2.33 0.020 R 3.99 0.780 0.0
AA + aA vs. aa High quality 1319 1662 8 1.34 (1.09-1.66) 2.75 0.006 R 7.41 0.390 6.0
BsmI
bb vs. BB Overall 841 855 8 1.79 (0.98-3.26) 1.89 0.060 R 18.93 0.008 63.0
bB vs. BB Overall 611 609 8 1.85 (1.03-3.32) 2.05 0.040 R 21.94 0.003 68.0
bb vs. bB Overall 966 856 8 0.96 (0.77-1.20) 0.33 0.740 R 5.01 0.660 0.0
bb + bB vs. BB Overall 1210 1160 8 1.81 (1.03-3.17) 2.07 0.040 R 23.82 0.001 71.0
bb + bB vs. BB Asian 738 640 3 1.21 (0.67-2.32) 0.69 0.490 R 3.10 0.210 36.0
bb + bB vs. BB Caucasian 472 520 5 2.43 (1.02-5.80) 2.00 0.050 R 19.52 <0.001 80.0
bb + bB vs. BB Hypercalciuria 123 340 3 2.43 (1.36-4.35) 2.99 0.003 R 1.99 0.370 0.0
bb + bB vs. BB Adult 1146 1070 7 1.80 (0.96-3.38) 1.83 0.070 R 23.65 <0.001 75.0
bb + bB vs. BB HWE 909 820 5 1.36 (0.87-2.13) 1.35 0.180 R 4.90 0.300 18.0
bb + bB vs. BB High quality 794 709 3 1.15 (0.75-1.72) 0.66 0.510 R 1.01 0.600 0.0
FokI
ff vs. FF Overall 1144 1243 14 1.59 (1.08-2.35) 2.34 0.020 R 47.26 <0.001 72.0
fF vs. FF Overall 1647 1809 14 1.38 (0.96-2.00) 1.72 0.090 R 64.13 <0.001 80.0
ff vs. fF Overall 1741 1804 14 1.04 (0.74-1.45) 0.22 0.830 R 56.68 <0.001 77.0
ff + fF vs. FF Overall 2266 2418 14 1.48 (1.03-2.12) 2.12 0.030 R 68.26 <0.001 81.0
ff + fF vs. FF Asian 2005 2188 12 1.32 (0.94-1.86) 1.62 0.110 R 44.62 <0.001 75.0
ff + fF vs. FF Hypercalciuria 324 560 5 1.15 (0.81-1.63) 0.79 0.430 R 1.42 0.840 0.0
ff + fF vs. FF Adult 2024 1743 11 1.71 (1.14-2.56) 2.61 0.009 R 59.01 <0.001 83.0
ff + fF vs. FF HWE 1390 1125 7 1.05 (0.83-1.33) 0.39 0.700 R 8.54 0.200 30.0
ff + fF vs. FF High quality 1513 1348 7 1.34 (0.83-2.16) 1.19 0.230 R 53.59 <0.001 85.0
TaqI
tt vs. TT Overall 1144 1478 13 1.24 (0.92-1.68) 1.40 0.160 R 12.19 0.430 2.0
tT vs. TT Overall 1558 1786 13 1.33 (1.04-1.70) 2.28 0.020 R 21.41 0.040 44.0
tt vs. Tt Overall 806 624 13 0.92 (0.61-1.38) 0.40 0.690 R 21.56 0.040 44.0
tt + tT vs. TT Overall 1744 1944 13 1.30 (1.08-1.55) 2.79 0.005 R 13.54 0.330 11.0
tt + tT vs. TT Asian 1110 1386 6 1.39 (1.11-1.73) 2.87 0.004 R 4.32 0.500 0.0
tt + tT vs. TT Caucasian 644 558 7 1.21 (0.84-1.72) 1.02 0.310 R 10.06 0.120 40.0
tt + tT vs. TT Hypercalciuria 176 183 5 1.56 (1.06-2.31) 2.24 0.030 R 2.47 0.650 0.0
tt + tT vs. TT Adult 1481 1244 9 1.34 (1.05-1.71) 2.35 0.020 R 12.71 0.120 37.0
tt + tT vs. TT HWE 1098 964 7 1.36 (1.07-1.77) 2.51 0.010 R 7.44 0.280 19.0
tt + tT vs. TT High quality 1392 1676 8 1.27 (1.05-1.54) 2.43 0.010 R 9.23 0.240 24.0
ApaI-TaqI haplotype
At vs. aT Overall 830 1207 4 1.35 (1.09-1.68) 2.71 0.007 R 2.91 0.410 0.0
At vs. aT Asian 644 961 3 1.53 (1.17-2.00) 3.14 0.002 R 0.35 0.840 0.0
At vs. aT Adult 752 806 3 1.36 (1.03-1.80) 2.16 0.030 R 2.90 0.230 31.0

vs., versus; HWE, Hardy-Weinberg equilibrium; R, random-effects model.

Zhang et al.

Zhang et al. BMC Medical Genetics 2013 14:104   doi:10.1186/1471-2350-14-104

Open Data