Table 2

Analysis of association between SNPs and repeated measures of BMI z-score
Gene SNP Tested allele AGA SGA Adjusted for SGA status Interaction with SGA status (ref = AGA)
Estimate (95% CI) p value q value Estimate (95% CI) p value q value Estimate (95% CI) p value q value Estimate (95% CI) p value q value
ADIPOR2 rs2286385 T 0.165 (0.065-0.265) 0.0012 0.0073* 0.035 (−0.093-0.162) 0.5950 0.3941 0.110 (0.031-0.190) 0.0063 0.0207* −0.131 (−0.294-0.031) 0.1134 0.1176
BDNF rs6265 G 0.123 (0.002-0.244) 0.0470 0.0650 0.203 (0.040-0.365) 0.0146 0.0303* 0.159 (0.059-0.260) 0.0018 0.0095* 0.079 (−0.123-0.282) 0.4429 0.3117
CTNNBL1 rs16986921 T 0.231 (−0.023-0.484) 0.0742 0.0848 0.259 (−0.058-0.576) 0.1089 0.1160 0.245 (0.042-0.449) 0.0180 0.0346* 0.030 (−0.377-0.436) 0.8867 0.4992
CTNNBL1 rs6013029 T 0.295 (0.044-0.547) 0.0214 0.0368* 0.310 (−0.015-0.634) 0.0611 0.0764 0.303 (0.099-0.507) 0.0036 0.0149* 0.016 (−0.396-0.428) 0.9401 0.5099
CTNNBL1 rs6020395 C 0.185 (−0.043-0.413) 0.1108 0.1164 0.458 (0.126-0.791) 0.0069 0.0212* 0.303 (0.109-0.498) 0.0022 0.0108* 0.274 (−0.130-0.677) 0.1836 0.1608
CTNNBL1 rs6020712 A 0.309 (0.050-0.568) 0.0193 0.0357* 0.233 (−0.074-0.539) 0.1372 0.1352 0.270 (0.068-0.472) 0.0087 0.0227 −0.077 (−0.479-0.325) 0.7085 0.4432
CTNNBL1 rs6020846 G 0.219 (−0.008-0.446) 0.0591 0.0751 0.287 (−0.019-0.594) 0.0663 0.0794 0.251 (0.064-0.438) 0.0085 0.0227 0.068 (−0.315-0.452) 0.7265 0.4509
CTNNBL1 rs6096781 C 0.209 (−0.025-0.444) 0.0805 0.0894 0.313 (−0.103-0.729) 0.1408 0.1370 0.249 (0.034-0.464) 0.0232 0.0389 0.103 (−0.376-0.582) 0.6742 0.4320
CTNNBL1 rs6125962 C 0.204 (−0.017-0.424) 0.0700 0.0811 0.276 (−0.029-0.582) 0.0763 0.0859 0.237 (0.054-0.421) 0.0113 0.0241* 0.072 (−0.306-0.450) 0.7076 0.4432
FAIM2 rs7138803 A 0.117 (0.015-0.219) 0.0249 0.0407* −0.015 (−0.150-0.119) 0.8220 0.4799 0.059 (−0.023-0.141) 0.1609 0.1492 −0.132 (−0.301-0.037) 0.1250 0.1279
FTO rs6499640 A 0.051 (−0.043-0.145) 0.2905 0.2290 0.153 (0.046-0.260) 0.0050 0.0188* 0.097 (0.027-0.168) 0.0070 0.0212* 0.103 (−0.039-0.246) 0.1562 0.1466
FTO rs8050136 A 0.143 (0.042-0.243) 0.0055 0.0195* 0.137 (0.011-0.263) 0.0335 0.0489* 0.141 (0.062-0.219) 4.8e-04 0.0042* −0.005 (−0.166-0.158) 0.9569 0.5130
FTO rs9939609 A 0.148 (0.048-0.248) 0.0038 0.0150* 0.154 (0.028-0.279) 0.0164 0.0331* 0.300 (0.117-0.482) 1.8e-04 0.0021* 0.007 (−0.154-0.169) 0.9290 0.5099
HMGA2 rs1042725 C 0.104 (0.010-0.198) 0.0304 0.0470* 0.062 (−0.058-0.183) 0.3090 0.2411 0.087 (0.013-0.161) 0.0215 0.0368* −0.041 (−0.194-0.112) 0.6015 0.3951
KCTD15 rs11084753 A 0.067 (−0.036-0.169) 0.2019 0.1749 0.155 (0.037-0.274) 0.0104 0.0234* 0.103 (0.026-0.181) 0.0090 0.0227* 0.088 (−0.069-0.244) 0.2732 0.2199
MAF rs1424233 A 0.052(−0.042 -0.146) 0.2758 0.2199 −0.130 (−0.263-0.003) 0.0552 0.0725 −0.024 (−0.103-0.054) 0.5446 0.3669 −0.183 (−0.347- -0.020) 0.0280 0.0441*
MC4R rs12970134 A 0.290 (0.191-0.389) 1.0e-08 8.0e-07* −0.060 (−0.204-0.085) 0.4194 0.3061 0.153 (0.069-0.236) 3.3e-04 0.0033* −0.350 (−0.525- -0.174) 9.6e-05 0.0015*
MC4R rs17700633 A 0.120 (0.015-0.225) 0.0253 0.0407* −0.047 (−0.164-0.070) 0.4299 0.3080 0.044 (−0.035-0.123) 0.2762 0.2199 −0.167 (−0.325- -0.010) 0.0374 0.0536
MC4R rs17782313 C 0.204 (0.105-0.303) 5.6e-05 0.0011* −0.006 (−0.147-0.136) 0.9398 0.5099 0.122 (0.041-0.204) 0.0032 0.0140* −0.210 (−0.383- -0.037) 0.0176 0.0346*
MC4R rs4450508 A 0.189 (0.091-0.286) 1.5e-04 0.0019* 0.021 (−0.115-0.158) 0.7610 0.4622 0.122 (0.041-0.202) 0.0029 0.0134* −0.168 (−0.336-0.0) 0.0496 0.0674
MC4R rs502933 A 0.168 (0.070-0.266) 7.5e-04 0.0053* 0.009 (−0.129-0.148) 0.8944 0.4999 0.107 (0.027-0.188) 0.0092 0.0227* −0.159 (−0.329-0.011) 0.0665 0.0794
MTMR9 rs2293855 A 0.162 (0.063-0.261) 0.0013 0.0073* −0.039 (−0.156-0.079) 0.5208 0.3538 0.079 (0.003-0.156) 0.0427 0.0601 −0.199 (−0.353- -0.045) 0.0113 0.0241*
NEGR1 rs2568958 A −0.053 (−0.139-0.033) 0.2280 0.1953 0.135 (0.021-0.250) 0.0203 0.0364* 0.021 (0.048-0.090) 0.5526 0.3691 0.189 (0.046-0.332) 0.0097 0.0227*
NEGR1 rs2815752 T −0.059 (−0.146-0.028) 0.1810 0.1603 0.133 (0.021-0.245) 0.0195 0.0357* 0.017 (0.052-0.085) 0.6359 0.4108 0.193 (0.052-0.334) 0.0075 0.0214*
PTER rs10508503 C 0.307 (0.166-0.448) 2.1e-05 8.2e-04* −0.009 (−0.258-0.240) 0.9446 0.5099 0.190 (0.055-0.324) 0.0057 0.0195* −0.314 (−0.602- -0.026) 0.0327 0.0489*
SEC16B rs10913469 C 0.215 (0.089-0.341) 8.4e-04 0.0053* 0.199 (0.048-0.350) 0.0098 0.0227* 0.207 (0.110-0.305) 3.1e-05 8.2e-04* −0.016 (−0.213-0.181) 0.8759 0.4966
SH2B1 rs7498665 G −0.100 (−0.191- -0.008) 0.0334 0.0489* 0.163 (0.043-0.283) 0.0076 0.0214* 0.006 (−0.067-0.080) 0.8664 0.4966 0. 263 (0.112-0.414) 6.3e-04 0.0050*

* Remain significant after applying multiple testing correction using false discovery rate.

Han et al.

Han et al. BMC Medical Genetics 2013 14:10   doi:10.1186/1471-2350-14-10

Open Data