Table 3

Association of children’s fasting glucose, HbA1c levels, and genetic risk scores, with IQ at age 8
Exposure N (unadjusted/adjusted) Mean difference in IQ per unit change in exposure (95% CI) p-value Adjusted by child’s age and sex p-value
fasting glucose (mmol/l) 784/784 −1.94 (−4.71, 0.82) 0.17 −2.22 (−5.01, 0.56) 0.12
HbA1c (%) 1198/1198 0.43 (−2.53, 3.40) 0.78 0.65 (−2.29, 3.59) 0.67
Genetic risk score N (unadjusted/adjusted) Mean difference in IQ per weighted allele (95% CI) p-value Adjusted by PCs p-value
FGGRS 3904/3457 −0.09 (−0.26, 0.08) 0.29 −0.11 (−0.30, 0.07) 0.22
T2DGRS 3468/3053 0.01 (−0.15, 0.18) 0.87 0.06 (−0.12, 0.24) 0.52

FGGRS = fasting glucose genetic risk score.

T2DGRS = type 2 diabetes genetic risk score.

PCs = population stratification principal components.

Bonilla et al.

Bonilla et al. BMC Medical Genetics 2012 13:90   doi:10.1186/1471-2350-13-90

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