Table 1

Genetic variants related to fasting glucose concentration and type 2 diabetes examined in this study
Gene dbSNP id Alleles (major/minor) MAF mothers N = 6844* MAF children N = 7685* CEU Risk allele Reported associations
ADAMTS9 rs4607103 C/T 0.24 0.24 0.19 major T2D
ADCY5 rs2877716 C/T 0.26 0.26 0.25 major fasting glucose/T2D
ADIPOQ rs1501299 G/T n/t 0.27 0.27 minor T2D
ADIPOQ rs17300539 G/A n/t 0.09 0.08 minor T2D
ADIPOQ rs266729 C/G n/t 0.26 0.31 minor T2D
ADRA2A rs10885122 G/T 0.13 0.12 0.10 major fasting glucose
C2CD4B rs11071657 A/G 0.39 0.38 0.41 major fasting glucose
CDC123/CAMK1D rs12779790 A/G 0.18 0.19 0.22 minor T2D
CDKAL1 rs10946398 A/C 0.31 0.31 0.30 minor T2D
CDKN2A/B rs10811661 T/C 0.18 0.17 0.20 major T2D
COX2 rs20417 G/C 0.15 0.15 0.18 major T2D
CRY2 rs11605924 C/A 0.48 0.48 0.54 minor fasting glucose
DGKB/TMEM195 rs2191349 T/G 0.46 0.46 0.53 major fasting glucose/T2D
FADS1 rs174550 T/C 0.33 0.33 0.37 major fasting glucose
FTO rs9939609 T/A 0.40 0.40 0.45 minor obesity
G6PC2 rs560887 C/T 0.30 0.30 0.33 major fasting glucose
GCK rs1799884 G/A 0.18 0.18 0.20 minor fasting glucose/T2D
GCKR rs780094 C/T 0.39 0.39 0.38 major fasting glucose/T2D
GLIS3 rs7034200 C/A 0.47 0.48 0.53 minor fasting glucose
HHEX-IDE rs1111875 C/T 0.41 0.41 0.44 major T2D
HNF1B rs757210 C/T 0.37 0.37 0.43 minor T2D
IGF2BP2 rs4402690 G/T 0.31 0.30 0.29 minor T2D
JAZF1 rs864745 A/G 0.50 0.50 0.48 major T2D
KCNJ11 rs5219 C/T 0.35 0.35 0.50 minor T2D
KCNQ1 rs2237892 C/T 0.06 0.06 0.08 major T2D
KCNQ1 rs2237895 A/C 0.42 0.41 0.36 minor T2D
MADD rs7944584 A/T 0.28 0.28 0.29 major fasting glucose
MTNR1B rs10830963 C/G 0.27 0.28 0.30 minor fasting glucose/T2D
NOTCH2 rs10923931 G/T 0.11 0.11 0.09 minor T2D
PPARG rs1801282 C/G 0.12 0.11 0.07 major T2D
PROX1 rs340874 C/T 0.43 0.43 0.44 major fasting glucose/T2D
SLC2A2 rs11920090 T/A 0.12 0.13 0.13 major fasting glucose
SLC30A8 rs13266634 C/T 0.30 0.30 0.25 major fasting glucose/T2D
TCF7L2 rs12255372 G/T 0.29 0.29 0.22 minor fasting glucose
TCF7L2 rs7903146 C/T 0.30 0.30 0.25 minor fasting glucose/T2D
THADA rs7578597 A/G 0.11 0.11 0.08 major T2D
TSPAN8/LGR5 rs7961581 T/C 0.28 0.28 0.23 minor T2D
WFS1 rs10010131 G/A 0.40 0.40 0.26 major T2D

MAF = minor allele frequency.

T2D = type 2 diabetes.

n/t = not typed.

*N = mean of the total number of individuals typed for each SNP. Range in mothers: 2553–7151. Range in children: 7295–8323.

minor allele frequency in the HapMap CEPH European population.

risk allele for higher plasma fasting glucose or susceptibility to type 2 diabetes.

Bonilla et al.

Bonilla et al. BMC Medical Genetics 2012 13:90   doi:10.1186/1471-2350-13-90

Open Data