Table 4

Allelic distributions and related OR values
FPN1-8CG HFEH63D HFEC282Y HEPC-582AG TFP570S
Allele (%) C G H D C Y A G P S
All subjects (n=828) 629 (76.0) 199 (24.0) 689 (83.2) 139 (16.8) 802 (96.86) 26 (3.14) 585 (70.6) 243 (29.3) 678 (81.9) 150 (18.1)
OR (95%CI) 1.52 (1.2-1.93) 1.23 (0.94-1.6) 0.76 (0.45-1.27) 1.30 (1.05-1.62) 1.04 (0.81-1.34)
P uncorrected <0.0001 NS NS 0.020 NS
(P corrected) (<0.002) (NS) (NS) (NS) (NS)
RR (n=546) 416 (76.2) 130 (23.8) 457 (83.7) 89 (16.3) 532 (97.4) 14 (2.6) 402 (73.6) 144 (26.4) 453 (83.0) 93 (17.0)
OR (95%CI) 1.5 (1.15-1.95) 1.18 (0.88-1.6) 0.61 (0.33-1.16) 1.12 (0.88-1.44) 0.97 (0.73-1.29)
P uncorrected 0.004 NS NS NS NS
(P corrected) (NS) (NS) (NS) (NS) (NS)
PP + SP (n=282) 213(75.5) 69 (24.5) 232 (82.3) 50 (17.7) 270 (96.86) 12 (3.14) 183 (64.9) 99 (35.1) 225 (79.8) 57 (20.2)
OR (95%CI) 1.55 (1.12-2.15) 1.31 (0.91-1.88) 1.04 (0.53-2.03) 1.7 (1.27-2.27) 1.19 (0.85-1.68)
P uncorrected 0.010 NS NS <0.0001 NS
(P corrected) (NS) (NS) (NS) (<0.002) (NS)
OR1(95%CI) 1.03 (0.74-1.45) 1.10 (0.75-1.61) 1.7 (0.8-3.7) 1.51 (1.11-2.06) 1.23 (0.86-1.78)
P uncorrected NS NS NS 0.010 NS
(P corrected) (NS) (NS) (NS) (NS) (NS)
Controls (n=828) 685 (82.7) 143 (17.3) 711 (85.9) 117 (14.1) 794 (95.9) 34 (4.1) 628 (75.9) 200 (24.1) 683 (82.5) 145 (17.5)

All OR calculations are obtained computing the rare vs the common allele comparing cases vs controls. OR1 is referred to the Progressive group in which the reference category is the RR subgroup. Corrected and uncorrected P-values are respectively referred to the presence/absence of Bonferroni correction. NS, not significant.

Gemmati et al.

Gemmati et al. BMC Medical Genetics 2012 13:70   doi:10.1186/1471-2350-13-70

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