Table 1

Association of SNPs in theTLR7-TLR8region with AR phenotype in the Swedish population
Association test Skin prick test
Gene SNP ID Position* Alleles MAF HW Allele M + F Allele M Allele F Genotype Birch Timothy grass
TLR7 rs179021 12889763 T/G 0.22 0.25 0.60 0.54 0.82 0.50 0.64 0.061
TLR7 rs179020 12889857 G/A 0.24 0.32 0.40 0.71 0.16 0.36 0.17 0.49
TLR7 rs179019 12889969 C/A 0.24 0.32 0.41 0.69 0.16 0.36 0.17 0.49
TLR7 rs179016 12894442 G/C 0.36 0.52 0.34 0.31 0.69 0.61 0.90 0.14
TLR7 rs179014 12899765 G/A 0.24 0.13 0.58 0.65 0.25 0.45 0.19 0.43
TLR7 rs179013 12901471 G/A 0.22 0.44 0.42 0.50 0.56 0.63 0.42 0.095
TLR7 rs179012 12901562 G/A 0.29 0.98 0.67 0.68 0.84 0.83 0.32 0.28
TLR7 rs179011 12901960 G/T 0.23 0.20 0.41 0.63 0.44 0.57 0.46 0.093
TLR7 rs179010 12902885 C/T 0.31 0.012 0.47 0.95 0.26 0.55 0.97 0.90
TLR7 rs179008 12903659 A/T 0.22 0.16 0.29 0.38 0.47 0.44 0.39 0.11
TLR7 rs864058 12906030 G/A 0.07 0.80 0.37 0.29 0.65 0.56 0.44 0.44
TLR7 rs179007 12910322 A/G 0.23 0.81 0.53 0.50 0.90 0.87 0.20 0.21
TLR7 rs179006 12910521 G/A 0.20 0.61 0.17 0.46 0.30 0.43 0.42 0.22
TLR7 rs2269809 12910619 G/T 0.50 0.057 0.58 0.91 0.40 0.028 (0.064) 0.81 0.054
TLR7 rs5935438 12913022 G/C 0.45 0.21 0.28 0.99 0.22 0.0059 (0.064) 0.81 0.019 (0.051)
TLR8 rs178998 12917787 C/T 0.34 0.045 0.19 0.86 0.080 0.15 0.10 0.23
TLR8 rs3788935 12922659 A/G 0.23 0.53 0.0036 (0.076) 0.36 0.0037 (0.046) 0.012 (0.064) 0.44 0.23
TLR8 rs3761624 12923681 A/G 0.22 0.62 0.0080 (0.076) 0.49 0.0056 (0.046) 0.016 (0.064) 0.40 0.16
TLR8 rs5741883 12924221 C/T 0.25 0.96 0.28 0.96 0.17 0.068 0.67 0.038 (0.054)
TLR8 rs17256081 12926045 T/C 0.49 0.11 0.80 0.64 0.98 0.021 (0.064) 0.76 0.0066 (0.035)
TLR8 rs4830805 12927759 G/A 0.21 0.92 0.0069 (0.076) 0.25 0.013 (0.071) 0.042 (0.064) 0.34 0.080
TLR8 rs1548731 12927947 C/T 0.27 0.93 0.50 0.89 0.48 0.046 (0.064) 0.94 0.49
TLR8 rs4830808 12932334 C/T 0.16 0.44 0.70 0.53 0.38 0.55 0.24 0.22
TLR8 rs2407992 12939112 G/C 0.38 0.068 0.63 0.75 0.40 0.67 0.42 0.040 (0.054)

The Hardy-Weinberg (HW) test uses both cases and controls. Male (M) and Female (F) individuals were used separately and combined in the allele tests. The Kruskal-Wallis test is used on skin prick data. P-values are given for the HW and the association tests. Q-values are given in parenthesis.

*Position according to NCBI build 37.1. Allele frequency of second allele.

Nilsson et al.

Nilsson et al. BMC Medical Genetics 2012 13:66   doi:10.1186/1471-2350-13-66

Open Data