Open Access Highly Accessed Research article

Toll-like receptor gene polymorphisms are associated with allergic rhinitis: a case control study

Daniel Nilsson12*, Anand Kumar Andiappan3, Christer Halldén24, Wang De Yun5, Torbjörn Säll6, Chew Fook Tim3 and Lars-Olaf Cardell1

Author Affiliations

1 Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

2 Biomedicine, Kristianstad University, Kristianstad, Sweden

3 Department of Biological Sciences, National University of Singapore, Science Drive 4, Singapore, Singapore, 117543

4 Department of Laboratory medicine, Lund University, Skåne University Hospital, Malmö, Sweden

5 Department of Otolaryngology, National University of Singapore, 10 Lower Kent Ridge Road, Singapore, Singapore, 119260

6 Department of Cell and Organism Biology, Lund University, Lund, Sweden

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BMC Medical Genetics 2012, 13:66  doi:10.1186/1471-2350-13-66

Published: 2 August 2012

Additional files

Additional file 1:

Investigated genes and number of attempted and genotyped SNPs.

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Additional file 2:

Description of genotyped SNPs.

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Additional file 3:

Description of genotyping and association testing in the two populations.

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Additional file 4:

Complete first experiment association test results in the Swedish population.

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Additional file 5:

Allele and genotype frequencies for all significant SNPs in the Swedish population.

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Additional file 6:

Linkage disequilibrium plot ofTLR7-TLR8gene region constructed using Haploview software and HapMap data (release 24) of the A) CEU population and B) CHB population. The intensity of shading represents D´. S SNPs showing single-point association in the Swedish population. C SNPs showing single-point association in the Chinese population. D SNPs showing single-point association in Møller-Larsen et al. (2008).

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Additional file 7:

Allele frequencies in Chinese males for all significant SNPs

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