Table 1

Index SNPs for regions underp= 10-6
SNP Chr Position Gene Allele MAF HWE <a onClick="popup('http://www.biomedcentral.com/1471-2350/13/53/mathml/M4','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2350/13/53/mathml/M4">View MathML</a> <a onClick="popup('http://www.biomedcentral.com/1471-2350/13/53/mathml/M5','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2350/13/53/mathml/M5">View MathML</a> p-value β
rs7816345 8 36846109 ZNF703 C/T 0.194 0.08 1.00 1.00 1.64·10−14 -0.151 (-0.189 – -0.112)
rs4849887 2 121245122 INHBB C/T 0.113 0.97 1.00 0.94 3.31·10−11 0.166 (0.117 – 0.214)
rs17625845 2 121089731 INHBB T/C 0.205 0.07 0.72 0.99 4.7·10−10 0.125 (0.086 – 0.164)
rs12173570 6 151957714 ESR1 C/T 0.101 0.82 0.98 0.99 5.58·10−11 0.171 (0.120 – 0.222)
rs7089814 10 64187564 ZNF365 T/C 0.375 0.97 0.94 0.98 3.3·10−9 0.096 (0.064 – 0.128)
rs12371778 12 28156081 PTHLH C/G 0.091 0.72 0.85 0.87 1.03·10−8 -0.162 (-0.217 – -0.106)
rs62314947 4 75502487 AREG C/T 0.281 0.31 0.73 0.91 4.79·10−8 -0.101 (-0.137 – -0.065)
rs4820792 22 29161007 CHEK2 C/T 0.180 0.01 0.95 0.97 4.17·10−7 0.105 (0.065 – 0.146)
chr22:40779964 22 40779964 MKL1 G/A 0.056 0.05 0.75 0.78 5.47·10−7 -0.187 (-0.261 – -0.114)
rs61280460 14 94796184 SERPINA6 A/T 0.199 0.29 1.00 1.00 8.3·10−7 -0.095 (-0.132 – -0.057)

The index SNP is defined as the SNP with the smallest p-value within a region; or the SNP with the smallest p-value in the conditional analysis. The listed gene is our postulated candidate gene near the SNP. For INHBB, conditional analysis revealed two independent SNPs in the region. Alleles are listed as major/minor (in Europeans). MAF is the frequency of the minor allele in Europeans and <a onClick="popup('http://www.biomedcentral.com/1471-2350/13/53/mathml/M6','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2350/13/53/mathml/M6">View MathML</a> and <a onClick="popup('http://www.biomedcentral.com/1471-2350/13/53/mathml/M7','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2350/13/53/mathml/M7">View MathML</a> are the estimated imputation accuracies on the two genotyping platforms. HWE is the p-value for Hardy-Weinberg equilibrium (calculated on rounded dosages). The coefficient βrefers to the average change in breast size (in units of cup size) per copy of the minor allele.

Eriksson et al.

Eriksson et al. BMC Medical Genetics 2012 13:53   doi:10.1186/1471-2350-13-53

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