Open Access Highly Accessed Research article

Computational identification and experimental validation of microRNAs binding to the Alzheimer-related gene ADAM10

Regina Augustin1, Kristina Endres2, Sven Reinhardt2, Peer-Hendrik Kuhn3, Stefan F Lichtenthaler3, Jens Hansen1, Wolfgang Wurst134* and Dietrich Trümbach14*

Author Affiliations

1 Helmholtz Centre Munich, German Research Centre for Environmental Health (GmbH) and Technical University Munich, Institute of Developmental Genetics, Ingolstädter Landstraße. 1, 85764, Munich-Neuherberg, Germany

2 Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg-University Mainz, Untere Zahlbacher Str. 8, 55131, Mainz, Germany

3 DZNE-German Center for Neurodegenerative Diseases, Schillerstrasse 44, 80336, Munich, Germany

4 Max Planck Institute of Psychiatry, Kraepelinstr. 2-10, 80804, Munich, Germany

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BMC Medical Genetics 2012, 13:35  doi:10.1186/1471-2350-13-35

Published: 17 May 2012

Additional files

Additional file 1:

List of predicted target genes common in 4 out of 6 DBs. The table shows a list of predicted target genes of miR-103, miR-107, miR-1306. These target genes are either listed in AlzGene DB and target gene of at least one miRNA or target gene of at least two miRNAs (column 3). Beside the gene symbol the Entrez GeneID is given.

Format: XLS Size: 25KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

List of enriched target genes of miR-103 in Gene Ontology. The table shows the Gene Ontology entities with enrichment of predicted target genes of miR-103. Additionally a p-value and FDR value is given.

Format: XLS Size: 49KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 3:

List of enriched target genes of miR-107 in Gene Ontology. The table shows the Gene Ontology entities with enrichment of predicted target genes of miR-107. Additionally a p-value and FDR value is given.

Format: XLS Size: 52KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 4:

List of enriched target genes of miR-1306 in Gene Ontology. The table shows the Gene Ontology entities with enrichment of predicted target genes of miR-1306. Additionally a p-value and FDR value is given.

Format: XLS Size: 118KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data