Table 3

Association of theCOX-2variants with CIMT, Cdist and cholesterol values.
Phenotype Variant Minor/major P P Q Measured mean value Number of individuals
allele unadjusted adjusted† adjusted †† hommajor het hom minor hom major het hom minor total
Mean carotid intima-media thickness (mm) rs4648261 A/G 0.046 0.116 0.896 0.58 0.57 0.53 1583 99 4 1686
Max carotid intima-media thickness (mm) rs4648261 A/G 0.048 0.121 0.477 0.62 0.61 0.56 1583 99 4 1686
Carotid distensibility (% /10 mmHg) rs689470 T/C 0.005 0.031 0.137 2.17 2.42 2000 71 2071
rs689462 C/A 0.005 0.031 0.137 2.17 2.42 2000 71 2071
Total cholesterol (mmol/l) rs5275 C/T 0.014 0.007 0.017 5.20 5.11 5.05 955 930 208 2093
LDL cholesterol (mmol/l) rs5275 C/T 0.009 0.006 0.022 3.31 3.24 3.16 940 921 204 2065

† linear regression model, adjusted with gender, age, BMI and smoking status.

†† false discovery rate corrected p-values (= q-values) adjusted with gender, age, BMI and smoking status.

hom major = major allele homozygote, het = heterozygote, hom minor = minor allele homozygote.

Lähteelä et al.

Lähteelä et al. BMC Medical Genetics 2012 13:32   doi:10.1186/1471-2350-13-32

Open Data