Table 3

Association of HbA1cwith the 11 SNP genetic risk score by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III)
Race/ethnicity β (SE)1 p-value2 Sample N Genetic Risk Score (SE)4 R2 Without Score3 R2With Score3 R2 Difference HbA1c(%) difference top - bottom 10% of score distribution
Non-Hispanic White
HbA1c(%) 0.012 (0.006) 0.04 1231 10.42 (0.07) 0.214 0.218 0.004 0.49
Non-Hispanic Black
HbA1c(%) 0.007 (0.008) 0.39 901 10.95 (0.09) 0.095 0.096 0.001 0.56
Mexican Americans
HbA1c(%) 0.021 (0.008) 0.005 909 10.67 (0.08) 0.131 0.168 0.037 0.54

HbA1c: Hemoglobin A1c (glycated hemoglobin); SE: standard error.

1. β-coefficients (SE) for the per-risk allele increase in HbA1c (%) from linear regression models fro the risk score adjusted for age and sex.

2. p-values for β-coefficients based on Satterthwaite adjusted-F test.

3. Adjusted R2 for regression models with and without (age and sex only) weighted genetic risk score.

4. p = <.0001 for the global difference in weighted genetic risk score across race-ethnic groups.

Grimsby et al.

Grimsby et al. BMC Medical Genetics 2012 13:30   doi:10.1186/1471-2350-13-30

Open Data