|Association of HbA1cwith the 11 SNP genetic risk score by race-ethnicity, Third National Health and Nutrition Examination Survey (NHANES III)|
|Race/ethnicity||β (SE)1||p-value2||Sample N||Genetic Risk Score (SE)4||R2 Without Score3||R2With Score3||R2 Difference||HbA1c(%) difference top - bottom 10% of score distribution|
|HbA1c(%)||0.012 (0.006)||0.04||1231||10.42 (0.07)||0.214||0.218||0.004||0.49|
|HbA1c(%)||0.007 (0.008)||0.39||901||10.95 (0.09)||0.095||0.096||0.001||0.56|
|HbA1c(%)||0.021 (0.008)||0.005||909||10.67 (0.08)||0.131||0.168||0.037||0.54|
HbA1c: Hemoglobin A1c (glycated hemoglobin); SE: standard error.
1. β-coefficients (SE) for the per-risk allele increase in HbA1c (%) from linear regression models fro the risk score adjusted for age and sex.
2. p-values for β-coefficients based on Satterthwaite adjusted-F test.
3. Adjusted R2 for regression models with and without (age and sex only) weighted genetic risk score.
4. p = <.0001 for the global difference in weighted genetic risk score across race-ethnic groups.
Grimsby et al.
Grimsby et al. BMC Medical Genetics 2012 13:30 doi:10.1186/1471-2350-13-30