Table 3

Distribution of cGRS, wGRS, and demographic characteristic of case patients and control subjects
Variable Case no. (%) Control no. (%) Logistic regression† OR (95% CI) P for trend ROC AUC/c statistic
(95% CI) (BOC)
cGRS (count risk allele)
0-1 125 (5.48) 226 (8.11) 1.00 (ref.) <0.001 0.542 (0.525-0.557)‡
2 337 (14.76) 465 (15.70) 1.31 (1.01-1.70) (0.540)*
3 589 (25.80) 733 (26.32) 1.45 (1.14-1.85)
4 600 (26.28) 740 (26,57) 1.47 (1.15-1.87)
5 435 (19.05) 453 (16.27) 1.74 (1.35-2.34)
≧6 197 (8.63) 168 (6.03) 2.12 (1.57-2.86)
wGRS (weighted genetic risk score)
0 (<Q10) 222 (9.72) 400 (14.36) 1.00 (ref.) <0.001 0.551 (0.532-0.564)‖
1 (Q10-Q20) 192 (8.41) 241 (8.65) 1.44 (1.12-1.84) (0.550)*
2 (Q20-Q30) 211 (9.24) 272 (9.77) 1.40 (1.10-1.78)
3 (Q30-Q40) 215 (9.42) 299 (10.74) 1.30 (1.02-1.65)
4 (Q40-Q50) 423 (18.53) 512 (18.38) 1.49 (1.21-1.83)
5 (Q50-Q60) 102 (4.47) 115 (4.13) 1.60 (1.17-2.19)
6 (Q60-Q70) 140 (6.13) 173 (6.21) 1.46 (1.11-1.92)
7 (Q70-Q80) 185 (8.10) 195 (7.00) 1.71 (1.38-2.22)
8 (Q80-Q90)) 309 (13.53) 323 (11.60) 1.72 (1.38-2.16)
9 (≧Q90)) 284 (12.44) 255 (9.16) 2.01 (1.59-2.54)
Age (mean±SD) 60.09±10.29 60.56±9.58
Age group
1 (≦60 year) 1113 (48.75) 1360 (48.53) 1.00 (ref.) 0.954 -
2(>60 year) 1170 (51.25) 1425 (51.17) 1.00 (0.90-1.12)
Gender
Male 1683 (73.72) 2039 (73.21) 1.00 (ref.) 0.686 -
Female 600 (26.28) 746 (26.79) 0.97 (0.86-1.11)
Smoking status
Never 801 (35.09) 1517 (54.47) 1.00 (ref.) <0.001 0.619 (0.603-0.634)※
Light-smokers 416 (18.22) 542 (19.46) 1.45 (1.25-1.70) (0.618)*
Heavy-smokers 1066 (46.69) 726 (26.07) 2.78 (2.45-3.16)

NOTE: CI, confidence interval; OR, odds ratio.

* Bootstrap optimism corrected estimate of model performance based on 1000 bootstrap resampling.

† Log-additive model.

‡ AUC value of model that only contain cGRS.

‡ AUC value of model that only contain wGS.

※AUC value of model that only contain smoking status.

Li et al.

Li et al. BMC Medical Genetics 2012 13:118   doi:10.1186/1471-2350-13-118

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