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Open Access Research article

Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level

Semon Wu12, Lung-An Hsu34, Ming-Sheng Teng2, Jeng-Feng Lin5, Hsien-Hsun Chang2, Yu-Chen Sun6, Hsuan-Pu Chen7 and Yu-Lin Ko58*

Author Affiliations

1 Department of Life Science, Chinese Culture University, Taipei, Taiwan

2 Department of Medical Research, Buddhist Tzu Chi General Hospital, Taipei Branch, Taipei, Taiwan

3 The First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan

4 Chang Gung University College of Medicine, Taipei, Taiwan

5 Division of Cardiology, Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Taipei branch, 289 Jianguo Road, Xindian City, Taipei, 231, Taiwan

6 Department of Laboratory Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan

7 Department of Neurology, University of California, San Francisco, USA

8 School of Medicine, Tzu Chi University, Hualien, Taiwan

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BMC Medical Genetics 2012, 13:115  doi:10.1186/1471-2350-13-115

Published: 29 November 2012

Abstract

Background

E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.

Methods

Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.

Results

SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).

Conclusion

SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.

Keywords:
E-selectin; Genetic association study; Polymorphism; Matrix metalloproteinase 9; Haplotype; Interaction