Table 6

Comparison of the haplotype frequencies between the healthy subjects and the HIV/AIDS patients
Haplotypes Healthy subjects n (freq) HIV/AIDS patients n (freq) Efavirenz levels (μg/mL)* Global p-value#
NR1I2 haplotypes [rs2472677-rs3732356-rs6785049]
C-T-A 7 (0.025) 6 (0.012) 2.13
C-T-G 109 (0.367) 190 (0.379) 4.00
C-G-G 64 (0.216) 114 (0.226) 6.69 0.015
T-T-A 16 (0.052) 6 (0.011) 4.94
T-T-G 96 (0.321) 172 (0.343) 4.23
T-G-G 6 (0.019) 13 (0.026) 4.55
NR1I3 haplotypes [rs2307424-rs2502815-rs3003596]
C-C-T 153 (0.489) 310 (0.530) 4.97
C-C-C 58 (0.187) 122 (0.208) 3.45
C-T-T 7 (0.023) 8 (0.013) 3.53 0.424
C-T-C 75 (0.240) 121 (0.207) 3.87
T-C-T 14 (0.045) 22 (0.037) 4.42
T-C-C 4 (0.012) 3 (0.005) 1.89

*Efavirenz levels are for the HIV/AIDS patients only; #Global p-value is for comparison of haplotype frequencies between healthy subjects and HIV/AIDS patients.

Swart et al.

Swart et al. BMC Medical Genetics 2012 13:112   doi:10.1186/1471-2350-13-112

Open Data