Open Access Research article

PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients

Marelize Swart1, Heather Whitehorn1, Yuan Ren2, Peter Smith2, Rajkumar S Ramesar1 and Collet Dandara1*

Author Affiliations

1 Division of Human Genetics, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa

2 Department of Clinical Pharmacology, Faculty of Health Sciences, University of Cape Town, Observatory, Cape Town 7925, South Africa

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BMC Medical Genetics 2012, 13:112  doi:10.1186/1471-2350-13-112

Published: 22 November 2012

Additional files

Additional file 1:

Table S1. PCR-RFLP and SNaPshot genotyping of SNPs in NR1I2 and NR1I3 and sequencing of NR1I2 and NR1I3 DNA binding domains.

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Additional file 2:

Figure S1. Chromatograms of the novel variants at position NR1I2 36726T>C in intron 1, NR1I2 36857G>A (allele change according to the reverse sequence) in exon 2 and NR1I2 36905C>T in exon 2.

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