Table 1 |
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|
Allelic and genotypic frequencies of -1082G > A and -592C > A IL-10 gene promoter variants |
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|
Males |
Females |
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|
|
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|
Control (n = 201) |
Schizophrenia (n = 153) |
OR (95%CI) |
P |
Control (n = 234) |
Schizophrenia (n = 88) |
OR (95% CI) |
P |
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|
|
||||||||||||
|
Age (years) |
37 ± 18 |
45 ± 13 |
0.000* |
39 ± 18 |
46 ± 13 |
0.002* |
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|
|
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|
-1082G > A Allelic frequencies |
n |
% |
n |
% |
p |
n |
% |
n |
% |
|||
|
G |
164 |
40.8% |
111 |
36.3% |
1.21 (0.88-1.66) |
0.252 |
198 |
42.3% |
57 |
32.4% |
1.53 (1.04-2.25) |
0.027* |
|
A |
238 |
59.2% |
195 |
63.7% |
270 |
57.7% |
119 |
67.6% |
||||
|
Genotypic frequencies |
||||||||||||
|
G/G |
38 |
18.9% |
23 |
15.0% |
0.502 |
33 |
14.1% |
11 |
12.5% |
0.008* |
||
|
G/A |
88 |
43.8% |
65 |
42.5% |
132 |
56.4% |
35 |
39.8% |
||||
|
A/A |
75 |
37.3% |
65 |
42.5% |
69 |
29.5% |
42 |
47.7% |
||||
|
|
||||||||||||
|
-592 C > A Allelic frequencies |
n |
% |
n |
% |
OR (95%CI) |
p |
n |
% |
n |
% |
OR (95% CI) |
p |
|
C |
274 |
75.7% |
227 |
72.8% |
1.11 (0.77-1.60) |
0.618 |
298 |
74.5% |
123 |
69.1% |
0.76 (0.51-1.15) |
0.213 |
|
A |
88 |
24.3% |
79 |
25.3% |
102 |
25.5% |
53 |
29.8% |
||||
|
Genotypic frequencies |
||||||||||||
|
C/C |
110 |
60.8% |
84 |
53.8% |
0.134 |
106 |
53.0% |
47 |
52.8% |
0.004* |
||
|
C/A |
54 |
29.8% |
59 |
37.8% |
86 |
43.0% |
29 |
32.6% |
||||
|
A/A |
17 |
9.4% |
10 |
6.4% |
8 |
4.0% |
12 |
13.5% |
||||
|
|
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|
Almoguera et al. BMC Medical Genetics 2011 12:81 doi:10.1186/1471-2350-12-81 |
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