Table 1

A list of SNPs with significantly higher global FST (P < 0.05)

SNPs

Trait

Gene

RAF

Global FST

P value

Pcor


rs1378942

Diastolic blood pressure [17]

CSK

0.708 (G)

0.247

0.025

0.022

rs653178

Diastolic blood pressure [17]

ATXN2

0.177 (G)

0.205

0.049

0.031

rs174570

Total, HDL and LDL cholesterol [36]

FADS2

0.730 (C)

0.351

0.002

0.000

rs4796217

Macrophage-mediated inflammation [37]

CCL4L2

0.425 (T)

0.221

0.040

0.032

rs602662*

Folate pathway [22,38]

FUT2

0.294 (A)

0.240

0.027

0.028

rs9388489

Type 1 diabetes [39]

C6orf97

0.634 (G)

0.308

0.008

0.002

rs3184504*

Type 1 diabetes [39]; diastolic blood pressure and systolic blood pressure[17]

SH2B3

0.179 (T)

0.210

0.045

0.031

rs6499640

BMI and weight[40]

FTO

0.455 (A)

0.208

0.045

0.037


RAF: risk allele frequency; Pcor, P value after correcting for minor allele frequency; CSK, c-src tyrosine kinase; ATXN2, ataxin 2; FADS2, fatty acid desaturase 2; CCL4L2, chemokine (C-C motif) ligand 4-like 2; FUT2, fucosyltransferase 2; C6orf97, chromosome 6 open reading frame 173; SH2B3, SH2B adaptor protein 3; FTO, fat mass and obesity associated

*, non-synonymous SNPs

Ding and Kullo BMC Medical Genetics 2011 12:55   doi:10.1186/1471-2350-12-55

Open Data