Table 3

Multiple-SNP nonepistatic and single SNP models: odds ratios (OR), and 95% confidence intervals for all main effects of SNPs.

Additive effects

Dominance effects


Nonepistatic

Model 1a

Model 2

Model 3

Model 1

Model 2

Model 3


rs9939609

0.919

(0.56-1.50)

0.935

(0.56-1.55)

0.956

(0.57-1.61)

0.780

(0.52-1.17)

0.796

(0.52-1.20)

0.778

(0.50-1.12)


rs1477196

2.379**

(1.46-3.87)

2.436**

(1.48-4.00)

2.611**

(1.56-4.37)

0.820

(0.55-1.22)

0.787

(0.52-1.17)

0.727

(0.47-1.10)


rs7206790

1.573

(0.97-2.54)

1.599

(0.98-2.61)

1.652

(0.98-2.78)

1.131

(0.76-1.68)

1.140

(0.76-1.70)

1.155

(0.76-1.76)


rs8047395

0.772

(0.45-1.30)

0.811

(0.47-1.38)

0.787

(0.45-1.37)

1.017

(0.66-1.55)

1.041

(0.67-1.60)

1.073

(0.68-1.69)


Additive effects

Dominance effects


Single SNP

Model 1a

Model 2

Model 3

Model 1

Model 2

Model 3


rs9939609

0.997

(0.79,1.25)

0.975

(0.77,1.23)

0.992

(0.78, 1.26)

0.814

(0.59,1.13)

0.831

(0.60,1.16)

0.776

(0.55,1.09)


rs1477196

1.390*

(1.10,1.76)

1.408*

(1.11,1.79)

1.447*

(1.13,1.85)

0.809

(0.58,1.13)

0.781

(0.56,1.09)

0.693*

(0.49,0.98)


rs7206790

1.066

(0.87,1.32)

1.054

(0.85,1.31)

1.022

(0.82,1.28)

0.969

(0.71,1.32)

0.980

(0.72,1.34)

0.949

(0.69,1.31)


rs8047395

1.052

(0.85,1.30)

1.054

(0.85,1.31)

1.075

(0.86,1.34)

0.878

(0.65,1.19)

0.876

(0.64,1.19)

0.812

(0.59.1.12)


*p-value < 0.01

**p-value < 0.001

a Model 1: without covariate; Model 2: adjust for race and age; Model 3: adjust for race, age and BMI

Kaklamani et al. BMC Medical Genetics 2011 12:52   doi:10.1186/1471-2350-12-52

Open Data