Open Access Highly Accessed Research article

The role of the fat mass and obesity associated gene (FTO) in breast cancer risk

Virginia Kaklamani1*, Nengjun Yi2, Maureen Sadim3, Kalliopi Siziopikou4, Kui Zhang5, Yanfei Xu6, Sarah Tofilon7, Surbhi Agarwal7, Boris Pasche8 and Christos Mantzoros9

Author Affiliations

1 Cancer Genetics Program, Division of Hematology/Oncology, Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 676 N St Clair st suite 850, Chicago, IL 60611,USA

2 Section on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, 1665 University Blvd, Ryals Bldg. 317F, Birmingham, AL 35294, USA

3 Cancer Genetics Program, Division of Hematology/Oncology, Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL60611, USA

4 Department of Pathology, Northwestern Memorial Hospital, 675 N St Clair st, Chicago, IL 60611, USA

5 Section on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, 1665 University Blvd, Ryals Bldg. 327H, Birmingham, AL 35294, USA

6 Division of Hematology/Oncology, Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA

7 Department of Medicine and Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 E Superior Street, Chicago, IL 60611, USA

8 Division of Hematology/Oncology and Comprehensive Cancer Center, University of Alabama, 1802 6th Avenue South, NP 2566, Birmingham, AL35294, USA

9 Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center (BIDMC), Harvard Medical School, 330 Brookline Avenue FD-876, Boston, MA 02215, USA

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BMC Medical Genetics 2011, 12:52  doi:10.1186/1471-2350-12-52

Published: 13 April 2011

Additional files

Additional file 1:

LD analysis for SNPs. Odds ratios (ORs) of three genotypes for the four SNPs under the epistatic model adjusted for race, age and BMI. The notation c, h, and r represent common homozygote, heterozygote, and rare homozygote, respectively.

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Additional file 2:

Odds ratios (ORs) of three genotypes for the four SNPs under the epistatic model adjusted for race, age and BMI. The notation c, h, and r represent common homozygote, heterozygote, and rare homozygote, respectively.

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Additional file 3:

Probablities of being case for two-locus genotypes at SNPs that show significant interactions under the epistatic model adjusted for race, age and BMI. The notation c, h, and r represent common homozygote, heterozygote, and rare homozygote, respectively.

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Additional file 4:

Receiver operating characteristic (ROC) curves for risk prediction for 1. epistatic model adjusted for race, age and BMI (dotted black line), 2. nonepistatic model adjusted for race, age and BMI (solid black line), and 3. model with covariates, race, age and BMI, and no SNPs. The areas under the ROC curves (AUC) are 0.68, 0.60, and 0.53, respectively.

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Additional file 5:

Results for FTO tissue expression. Results for FTO tissue expression.

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Additional file 6:

FTO expression according to ER, PR and her2 status. Tissue expression of FTO. TERneg: tumor ER negative, TERpos: tumor ER positive, TPRneg: tumor PR negative; TPRpos: tumor PR positive, THer2neg: Tumor Her2 negative, THer2pos: tumor Her2 positive. o = outliers, * = extreme cases.

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