Table 2 |
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|
Pearson's chi-square test for cases versus controls of SNPs and most frequent hgs |
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|
rCRS ref.a |
MAb |
MAFCAc |
MAFCOc |
CHI2 Exact |
P-value |
Adjusted P-valued |
OR (95% CI)e |
|
|
|
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|
3010G > A |
G |
A |
0.24 |
0.27 |
0.557 |
0.455 |
1 |
0.85 (0.56-1.29) |
|
3915G > A |
G |
A |
0.02 |
0.04 |
0.874 |
0.350 |
0.995 |
0.57 (0.17-1.89) |
|
3992C > T |
C |
T |
0.00 |
0.01 |
1.320 |
0.251 |
0.979 |
- |
|
4216T > C |
T |
C |
0.13 |
0.16 |
0.939 |
0.333 |
0.993 |
0.77 (0.46-1-30) |
|
4336T > C |
T |
C |
0.04 |
0.04 |
0.047 |
0.828 |
1 |
1.11 (0.45-2.72) |
|
4529A > T |
A |
T |
0.01 |
0.01 |
0.182 |
0.669 |
1 |
0.64 (0.08-5.13) |
|
4580G > A |
G |
A |
0.06 |
0.03 |
1.620 |
0.203 |
0.941 |
1.69 (0.75-3.82) |
|
4769A > G |
A |
A |
0.02 |
0.02 |
0.060 |
0.799 |
1 |
1.17 (0.34-4.04) |
|
4793A > C |
A |
G |
0.00 |
0.01 |
1.166 |
0.280 |
0.987 |
- |
|
6776T > C |
T |
C |
0.04 |
0.05 |
0.577 |
0.448 |
1 |
0.69 (0.27-1.79) |
|
7028C > T |
C |
C |
0.40 |
0.44 |
0.683 |
0.409 |
0.999 |
1.16 (0.81-1.67) |
|
10398A > G |
A |
G |
0.15 |
0.20 |
2.010 |
0.156 |
0.902 |
0.70 (0.43-1.15) |
|
10400C > T |
C |
T |
0.02 |
0.01 |
1.023 |
0.312 |
0.991 |
1.97 (0.52-7.52) |
|
10463T > C |
T |
C |
0.09 |
0.09 |
0.001 |
0.982 |
1 |
1.01 (0.53-1.92) |
|
10873T > C |
T |
C |
0.06 |
0.04 |
1.609 |
0.205 |
0.951 |
0.61 (0.28-1.32) |
|
12308A > G |
A |
G |
0.19 |
0.23 |
1.270 |
0.260 |
0.982 |
0.77 (0.49-1.21) |
|
12705C > T |
C |
T |
0.14 |
0.08 |
4.857 |
0.028 |
0.315 |
1.82 (1.06-3.13) |
|
13966A > G |
A |
G |
0.02 |
0.02 |
0.001 |
0.972 |
1 |
1.02 (0.29-3.58) |
|
14766C > T |
C |
T |
0.47 |
0.49 |
0.242 |
0.622 |
1 |
0.91 (0.64-1.31) |
|
H |
- |
- |
0.40 |
0.44 |
0.791 |
0.374 |
0.999 |
0.85 (0.59-1.22) |
|
H1 |
- |
- |
0.16 |
0.19 |
0.689 |
0.406 |
0.999 |
1.22 (0.76-1.96) |
|
HV |
- |
- |
0.52 |
0.50 |
0.121 |
0.728 |
1 |
1.06 (0.75-1.51) |
|
U |
- |
- |
0.19 |
0.23 |
1.248 |
0.264 |
0.983 |
1.29 (0.83-2.01) |
|
J |
- |
- |
0.03 |
0.08 |
4.411 |
0.036 |
0.390 |
2.61 (1.03-6.61) |
|
T |
- |
- |
0.09 |
0.08 |
0.077 |
0.782 |
1 |
0.92 (0.49-1.71) |
|
JT |
- |
- |
0.12 |
0.16 |
1.727 |
0.189 |
0.941 |
1.42 (0.84-2.41) |
|
|
||||||||
|
rCRS = revised Cambridge Reference Sequence; MA = minor allele; MAF = minimum allele frequency. arCRS: allele in the revised Cambridge Reference Sequence (rCRS)[41]; bMA: minor allele; cMAF: minimum allele frequency computed on cases (MAFCA) and control (MAFCO) individuals; dAdjusted P-value: adjustment of chi-square P-values was carried out with a permutation-based approach; number of permutations = 20,000; eOR (95%CI): ORs were computed with the rCRS allele as a reference |
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|
Álvarez-Iglesias et al. BMC Medical Genetics 2011 12:50 doi:10.1186/1471-2350-12-50 |
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