Table 2

Functional clusters of 1,493 CpGs (1,423 genes) with strongest correlations between levels of methylation and maternal age according to DAVID.

Terms

# Genes

Minimum DAVID p Value

Enrichment Score

Mesenchymal cell development/differentiation

11

0.003

2.53

Formation of mesoderm/primary germ layer

9

0.003

2.34

Neurological regulation

19

0.008

1.83

Regulation of glucose/carbohydrate metabolic process

8

0.01

1.83

Unsaturated fatty/icosanoid metabolism/biosynthesis

8

0.005

1.71

Negative regulation nucleocytoplasmic protein/transcription factor transport

5

0.006

1.70

Regulation nucleocytoplasmic protein/transcription factor transport

10

0.01

1.60

Limb morphogenesis

14

0.02

1.57

Phosphopantetheine-binding, acyl carrier activity

3

0.01

1.53

MADS-box

3

0.04

1.40

Helix-loop-helix

14

0.03

1.37

Positive regulation of glucose/carbohydrate metabolism

5

0.04

1.33

Negative regulation of phosphorylation

8

0.04

1.33

Regulation of transmembrane transport

6

0.03

1.32

Adkins et al. BMC Medical Genetics 2011 12:47   doi:10.1186/1471-2350-12-47