Table 5

The independent effects of admixture and ethnic identity upon dementia prevalence (weighted analysis)

Model 1

Model 2

Model 3

Model 4


APOE genotype


One or more e4 allele

2.21 (1.58-3.09)

p < 0.0011

2.19 (1.54-3.10)

p < 0.0011

2.13 (1.50-3.02)

p < 0.0011

2.45 (1.77-3.40)

p < 0.0011


Admixture


100% African versus 100% European admixture

1.53 (0.80-2.91)

p = 0.201

-

4.62 (1.48-14.5)

p = 0.011

2.55 (0.75-8.61)

p = 0.131


Ethnic identity

'White'

-

1 (ref)

1 (ref)

1 (ref)

'Mixed'

-

0.79 (0.47-1.33)

p = 0.381

0.54 (0.30-0.96)

p = 0.041

0.60 (0.34-1.09)

p = 0.091

'Black'

-

1.02 (0.68-1.51)

p = 0.931

0.50 (0.25-1.00)

p = 0.051

0.47 (0.22-1.02)

p = 0.061


Sociodemographic factors


Age (years)

-

-

-

1.10 (1.07-1.12)

p < 0.0011


Male sex

-

-

-

0.84 (0.59-1.21)

p = 0.36


Education (per level)

-

-

-

0.76 (0.64-0.90)

p = 0.001


1. p-values are taken from the model z-scores. It was not possible to run likelihood ratio tests because robust variance estimates were required given the use of sampling weights

Model 1 African admixture and APOE

Model 2 Ethnic identity and APOE

Model 3 African admixture, ethnic identity and APOE

Model 3 African admixture, ethnic identity, APOE, age, sex and education

Teruel et al. BMC Medical Genetics 2011 12:43   doi:10.1186/1471-2350-12-43

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