Table 3 |
|||||||
|
Distribution of predicted metabolic phenotypes and observed genotypes according to ethnic groups |
|||||||
|
Gene n (100%) |
Predicted phenotype |
Observed genotypes |
Amerindian 183 |
Caucasian descent 615 |
Mulatto 315 |
African descent 99 |
p value |
|
|
|||||||
|
UM |
*17/*17, *1/*17 |
38 (20.8%) |
150 (24.4%) |
94 (29.8%) |
32 (32.3%) |
0.048 |
|
|
EM |
*1/*1 |
114 (62.3%) |
289 (47.0%) |
128 (40.6%) |
33 (33.3%) |
<0.001 |
|
|
CYP2C19 |
IM |
*1/*2 |
16 (8.8%) |
110 (17.9%) |
63 (20.1%) |
19 (19.2%) |
0.010 |
|
PM |
*2/*2 |
7 (3.7%) |
32 (5.2%) |
11 (3.5%) |
6 (6.1%) |
0.549 |
|
|
Unknowna |
*2/*17 |
8 (4.4%) |
34 (5.5%) |
19 (6.0%) |
9 (9.1%) |
0.429 |
|
|
|
|||||||
|
CYP2C19*2 c.G681A (rs4244285); CYP2C19*17 c.C806T (rs12248560). UM: ultra-rapid metabolizer; EM: extensive metabolizer; IM: intermediate metabolizer; PM: poor metabolizer. a The predicted metabolic phenotypes of the *2/*17 genotypic combination is unknown. p values were calculated using Chi-square test. |
|||||||
|
Santos et al. BMC Medical Genetics 2011 12:13 doi:10.1186/1471-2350-12-13 |
|||||||
