Table 3

Distribution of predicted metabolic phenotypes and observed genotypes according to ethnic groups

Gene

n (100%)

Predicted phenotype

Observed genotypes

Amerindian

183

Caucasian descent

615

Mulatto

315

African descent

99

p value


UM

*17/*17, *1/*17

38 (20.8%)

150 (24.4%)

94 (29.8%)

32 (32.3%)

0.048

EM

*1/*1

114 (62.3%)

289 (47.0%)

128 (40.6%)

33 (33.3%)

<0.001

CYP2C19

IM

*1/*2

16 (8.8%)

110 (17.9%)

63 (20.1%)

19 (19.2%)

0.010

PM

*2/*2

7 (3.7%)

32 (5.2%)

11 (3.5%)

6 (6.1%)

0.549

Unknowna

*2/*17

8 (4.4%)

34 (5.5%)

19 (6.0%)

9 (9.1%)

0.429


CYP2C19*2 c.G681A (rs4244285); CYP2C19*17 c.C806T (rs12248560). UM: ultra-rapid metabolizer; EM: extensive metabolizer; IM: intermediate metabolizer; PM: poor metabolizer. a The predicted metabolic phenotypes of the *2/*17 genotypic combination is unknown. p values were calculated using Chi-square test.

Santos et al. BMC Medical Genetics 2011 12:13   doi:10.1186/1471-2350-12-13

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