Table 2

Allelic and genotypic frequencies of ABCB1 and CYP2C19 gene polymorphisms according to ethnic groups

Nucleotide Change and Genotype

n (100%)

Amerindian

183

Caucasian descent

615

Mulatto

315

African descent

99

p value


ABCB1 c.C3435T

CC

45 (24.6%)

206 (33.5%)

131 (41.6%)

47 (47.5%)

CT

88 (48.1%)

287 (46.7%)

142 (45.1%)

39 (39.4%)

<0.001

TT

50 (27.3%)

122 (19.8%)

42 (13.3%)

13 (13.1%)

T allele

51.4%

43.2%

35.9%

32.8%

<0.001

CYP2C19*2, c.G681A

GG

151 (83.1%)

439 (71.4%)

222 (70.5%)

65 (65.7%)

GA

24 (13.1%)

144 (23.4%)

82 (26.0%)

28 (28.3%)

0.013

AA

7 (3.8%)

32 (5.2%)

11 (3.5%)

6 (6.0%)

A allele

10.4%

16.9%

16.5%

20.2%

0.007

CYP2C19*17, c.C806T

CC

134 (73.2%)

425 (69.1%)

201 (63.8%)

55 (55.6%)

CT

40 (21.9%)

158 (25.7%)

94 (29.8%)

36 (36.4%)

0.065

TT

9 (4.9%)

32 (5.2%)

20 (6.4%)

8 (8.0%)

T allele

15.8%

18.0%

21.3%

26.3%

0.048


ABCB1c.C3435T (rs1045642); CYP2C19*2 c.G681A (rs4244285); CYP2C19*17 c.C806T (rs12248560). p values were calculated using Chi-square test.

Santos et al. BMC Medical Genetics 2011 12:13   doi:10.1186/1471-2350-12-13

Open Data