Table 1

Summary of SNP associations (based on multivariate p-value of < 5 × 10-8)

Chr

BP

SNP

Closest Gene

Minor/Major Allele

MAF

N

multivariate P-value

Associated Trait(s)

Univariate analysis


N

β*

SE

univariate p


1

109,619,361

rs660240

CELSR2

T/C

0.215

4883

7.0 × 10-9

LDL

11247

-0.170

0.017

2.1 × 10-22

HDL

11545

0.047

0.017

0.007

INS

2559

0.035

0.040

0.390

2

21,097,505

rs10199768

APOB

T/G

0.470

4872

2.3 × 10-8

LDL

11205

0.110

0.014

7.7 × 10-15

CRP

8878

-0.015

0.015

0.330

FERR

11285

0.032

0.014

0.020

3

166,973,974

rs1803274

BCHE

T/C

0.206

4883

2.4 × 10-42

BCHE

9171

-0.365

0.018

5.9 × 10-92

4

9,665,474

rs7671266

WDR1

T/C

0.208

4883

1.8 × 10-42

UA

11346

-0.305

0.017

9.3 × 10-71

4

9,940,392

rs4698036

Intergenic

G/T

0.218

4884

8.5 × 10-31

UA

11354

-0.257

0.017

2.3 × 10-52

8

19,894,037

rs17091905

LPL

A/G

0.124

4884

2.8 × 10-13

HDL

11546

0.150

0.022

5.7 × 10-12

TRIG

11576

-0.174

0.022

5.1 × 10-15

CRP

8918

0.062

0.024

0.008

BCHE

9168

-0.042

0.032

0.069

10

17,931,828

rs2437258

MRC1

T/C

0.226

4884

7.1 × 10-9

AST

11516

0.102

0.016

3.0 × 10-10

FERR

11332

0.015

0.016

0.350

TRIG

11579

0.027

0.017

0.116

ALT

11518

-0.012

0.017

0.460

12

119,955,720

rs3213545

OASL

A/G

0.295

4876

3.9 × 10-14

GGT

11493

-0.121

0.015

3.6 × 10-15

LDL

11228

0.066

0.016

2.9 × 10-5

CRP

8903

-0.066

0.017

8.8 × 10-5

TRIG

11556

0.021

0.016

0.180

15

56,465,804

rs10468017

LIPC

T/C

0.326

4864

2.8 × 10-11

HDL

11497

0.104

0.015

2.8 × 10-12

TRIG

11527

0.048

0.015

0.002

16

55,545,545

rs173539

CETP

T/C

0.324

4884

1.7 × 10-40

HDL

11549

0.255

0.015

3.3 × 10-65

LDL

11251

-0.050

0.015

0.001

19

50,087,459

rs2075650

TOMM40

G/A

0.152

4884

5.7 × 10-10

LDL

11248

0.153

0.020

1.6 × 10-14

CRP

8918

-0.116

0.021

4.2 × 10-8

HDL

11546

-0.105

0.020

8.1 × 10-8

TRIG

11576

0.098

0.020

9.6 × 10-7


SNPs highlighted in bold indicate the polymorphisms that are significantly associated with more than one trait; traits highlighted in bold are those which achieved significance in the univariate analysis.

* β represents 1 unit change in e.g. LDL (mmol/l) per copy increment in the minor allele; TRIG indicates triglycerides.

Middelberg et al. BMC Medical Genetics 2011 12:123   doi:10.1186/1471-2350-12-123

Open Data