Table 2

Epidermal growth factor receptor and K-ras mutations.

Site

Wild type

Type of point mutation

Number of mutations (%)

Amino acid

Heterozygous/homozygous


EGFRa

[SME1]

Exon 18

AAG

2183A>G

1 (33.3)

Gln849Leu

Heterozygous

Exon 21

CAG

2546A>T

1 (33.3)

Lys728Arg

Heterozygous

Exon 21

GCA

2611G>A

1 (33.3)

Ala871Thr

Heterozygous


K-ras

Codon 12

GGT

35G>A

16 (47.1)

Gly12Asp

Heterozygous

Codon 12

GGT

34G>T

6 (17.6)

Gly12Cys

Heterozygous

Codon 12

GGT

34G>A

3 (8.8)

Gly12Ser

Heterozygous

Codon 12

GGT

34G>A

1 (2.9)

Gly12Ser

Homozygous

Codon 12

GGT

34G>T

1 (2.9)

Gly12Cys

Homozygous

Codon 12

GGT

35G>C

1 (2.9)

Gly12Ala

Heterozygous

Codon 12

GGT

35G>A

1 (2.9)

Gly12Asp

Homozygous

Codon 12

GGT

35G>T

1 (2.9)

Gly12Val

Heterozygous

Codon 13

GGC

38G>A

1 (2.9)

Gly13Asp

Heterozygous

Codon 45

GTA

133G>A

1 (2.9)

Val45Ile

Homozygous

Codon 69

GAC

205G>A

1 (2.9)

Asp69Asn

Homozygous

Codon 80

TGT

239G>A

1 (2.9)

Cys80Tyr

Heterozygous


a Epidermal growth factor receptor.

Yunxia et al. BMC Medical Genetics 2010 11:34   doi:10.1186/1471-2350-11-34

Open Data